{"doi":"10.1038/sj.leu.2400598","title":"CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules","abstract":null,"journal":"Leukemia","year":1997,"id":647661,"datarank":6.192894569863148,"base_score":4.6443908991413725,"endowment":4.6443908991413725,"self_citation_contribution":0.6966586348712059,"citation_network_contribution":5.496235934991942,"self_endowment_contribution":0.6966586348712059,"citer_contribution":5.496235934991942,"corpus_percentile":null,"corpus_rank":null,"citation_count":103,"citer_count":100,"citers_with_citation_signal":94,"citers_with_endowment":94,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1687517,"name":"SW Van Gool","orcid":null,"position":1,"is_corresponding":false},{"id":1687518,"name":"P Vandenberghe","orcid":null,"position":2,"is_corresponding":false},{"id":1687520,"name":"M Bakkus","orcid":null,"position":3,"is_corresponding":false},{"id":1687521,"name":"K Thielemans","orcid":null,"position":4,"is_corresponding":false},{"id":1687522,"name":"MA Boogaerts","orcid":null,"position":5,"is_corresponding":false},{"id":1687523,"name":"JL Ceuppens","orcid":null,"position":6,"is_corresponding":false},{"id":1687515,"name":"LE Van den Hove","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules","abstract":"Our recent studies using various costimulatory molecules have demonstrated that antitumor effect could be induced by B7- or B70-transduced mouse tumors. To augment antitumor effect in vivo, the combination therapy with a costimulatory gene and a cytokine, interkeukin 12 (IL-12), gene to treat metastatic mouse lung tumor was investigated. We transfected with mouse B7 and/or IL-12 into mouse lung carcinoma 3LL, and three transfectants (IL-12/3LL, B7/3LL and IL-12/B7/3LL) were generated. CTL activity induced by the inoculation of IL-12/B7/3LL was increased about 10-fold compared with parental 3LL inoculation. We then examined the therapeutic efficacy of combination with B7 and IL-12-transduced tumors. Four weeks after 3LL inoculation, lung metastasis was significantly reduced by IL-12/B7/3LL post-inoculation, indicating that potent therapeutic antitumor immunity can be induced by combination with costimulators B7 and IL-12. Recently, it was reported that p40 subunit of IL-12 appeared to be a specific inhibitor for IL-12 heterodimer in vitro. To clarify the biological functions of p40 in vivo, we generated the myoblast transfectants which produced IL-12 p40 alone. Local production of IL-12 p40 from transfectant could suppress allogenic CTL induction and Th1-type antibodies (IgG2a/2b/3) production in vivo. Furthermore, IL-12 p40 producing myoblast are less susceptible to rejection compared with parental myoblast, indicating that IL-12 p40 gene transfer may be useful therapeutically in Th1-mediated transplantation and autoimmune disorders.","is_dataset_classified":null,"base_score":4.6443908991413725,"endowment":4.6443908991413725,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9096698","pmcid":null,"openalex_id":"https://openalex.org/W2052560076","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":2},{"year":2014,"count":4},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":3},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.springer.com/tdm","oa_locations":[{"url":"https://www.nature.com/articles/2400598.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/2400598","host_type":"publisher"},{"url":"https://doi.org/10.1038/sj.leu.2400598","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9096698","host_type":"repository"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9209458","host_type":"repository"}],"fields_of_study":["Chronic Lymphocytic Leukemia Research","Immune Cell Function and Interaction","T-cell and B-cell Immunology","B-Lymphocytes","B7-1 Antigen","CD40 Antigens","Cell Membrane","Humans","Isoantigens","Leukemia, Lymphoid","T-Lymphocytes, Cytotoxic","Tumor Cells, Cultured"],"mesh_terms":["B-Lymphocytes","Cell Membrane","Humans","Isoantigens","Leukemia, Lymphoid","T-Lymphocytes, Cytotoxic","Tumor Cells, Cultured","B7-1 Antigen","CD40 Antigens","Th1 Cells","Cell Line","Animals","Mice","Lung Neoplasms","Neoplasm Metastasis","Macromolecular Substances","Immunoglobulin G","Interleukin-12","Immunotherapy","Transfection","Antibody Formation","Dimerization","Genetic Therapy"],"keywords":["CD80","CD40","CD86","Cytotoxic T cell","IL-2 receptor","Biology","Chronic lymphocytic leukemia","Antigen-presenting cell","Immunology","T cell","Cancer research","Immune system","Leukemia","In vitro"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T01:42:07.924800Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}