{"doi":"10.1038/sj.ki.5002375","title":"Bone growth during daily or intermittent calcitriol treatment during renal failure with advanced secondary hyperparathyroidism","abstract":null,"journal":"Kidney International","year":2007,"id":657580,"datarank":1.1042268097064376,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.6475484440479242,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.6475484440479242,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":17,"citers_with_citation_signal":16,"citers_with_endowment":16,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1716575,"name":"Y.Z. 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Although calcitriol increased the serum calcium, it did not lower parathyroid hormone (PTH) or improve tibia and body length. Animals with renal failure and advanced secondary hyperparathyroidism had decreased PTH/PTHrP, which was accompanied by an increase in the cyclin kinase inhibitor p57(Kip2). Calcitriol treatment upregulated the PTH/PTHrP receptor but also increased inhibitors of cell proliferation such as p21(Waf1/Cip1), IGFBP3, and FGFR3. Calcitriol also enhanced markers of chondrocyte differentiation, such as IGF1, Vitamin D receptor, FGF23, and bone morphogenetic protein-7. Receptor activator of nuclear factor-kappabeta ligand levels improved with calcitriol treatment but without changes in osteoprotegerin suggesting an enhancement of osteo/chondroclastogenesis and mineralization. Overall, both daily and intermittent calcitriol had similar effects on endochondral bone growth in phosphorus-loaded rats with renal failure.","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17554252","pmcid":null,"openalex_id":"https://openalex.org/W1987129777","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"DK 56688-01","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R01DK056688-01","title":"REGULATION OF SKELETAL GROWTH IN RENAL FAILURE"}],"total_grants":2,"fwci":1.1018,"citation_percentile":0.75382025,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2015,"count":2},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":1}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.kidney-international.org/article/S0085253815526987/pdf","host_type":"journal"},{"url":"http://www.kidney-international.org/article/S0085253815526987/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0085253815526987?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0085253815526987?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1038/sj.ki.5002375","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17554252","host_type":"repository"},{"url":"http://dx.doi.org/10.1038/sj.ki.5002375","host_type":""},{"url":"https://dx.doi.org/10.1038/sj.ki.5002375","host_type":""}],"fields_of_study":["Parathyroid Disorders and Treatments","Bone health and treatments","Medical Imaging and Pathology Studies","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Animals, Suckling","Bone Development","Calcitriol","Cell Differentiation","Growth","Hyperparathyroidism, Secondary","Kidney Failure, Chronic","Parathyroid Hormone","Receptors, Parathyroid Hormone","Chondrocytes","Cell Proliferation","Rats"],"keywords":["Calcitriol","Secondary hyperparathyroidism","Endocrinology","Internal medicine","Hyperparathyroidism","Medicine","Calcitriol receptor","Parathyroid hormone","Renal osteodystrophy","Osteoprotegerin","Vitamin D and neurology","Receptor","Kidney disease","Activator (genetics)","Calcium","Bone Development","bone growth","Cell Differentiation","Growth","Animals, Suckling","Rats","Chondrocytes","Nephrology","growth plate","Animals","Kidney Failure, Chronic","Receptors, Parathyroid Hormone","Hyperparathyroidism, Secondary","Cell Proliferation"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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