{"doi":"10.1038/sj.gene.6363652","title":"A novel single nucleotide polymorphism and five probable haplotypes in the 5′ flanking region of the IL-6 gene in African-Americans","abstract":null,"journal":"Genes & Immunity","year":1999,"id":416019,"datarank":2.940304500477433,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":2.3832686904717866,"self_endowment_contribution":0.5570358100056463,"citer_contribution":2.3832686904717866,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":36,"citers_with_citation_signal":34,"citers_with_endowment":34,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1198509,"name":"J McNicholl","orcid":null,"position":1,"is_corresponding":false},{"id":1198510,"name":"LW Moreland","orcid":null,"position":2,"is_corresponding":false},{"id":1198511,"name":"S Louis Bridges","orcid":null,"position":3,"is_corresponding":false},{"id":1198508,"name":"M Osiri","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A novel single nucleotide polymorphism and five probable haplotypes in the 5′ flanking region of the IL-6 gene in African-Americans","abstract":"In order to identify novel single nucleotide polymorphisms (SNPs), we sequenced a 940 bp region of the 5' flanking region of the IL-6 gene in 63 normal African-Americans. We identified a biallelic (G/C) SNP at position -573 relative to the transcription start site (-573C allele frequency 0.095). This SNP, together with SNPs at -598 and -174, allows identification of five probable haplotypes. Haplotypes containing the -174C allele, which has been associated with lower plasma IL-6 levels, were uncommon (4%). These haplotypes may influence IL-6 gene transcription and thus may contribute to racial differences in the prevalence of inflammatory diseases.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11196667","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"PHS HHS","grant_id":"R01A-A44384","title":null}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.springer.com/tdm","oa_locations":[{"url":"https://www.nature.com/articles/6363652.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/6363652","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Humans","Interleukin-6","Haplotypes","Polymorphism, Single Nucleotide","United States","Promoter Regions, Genetic","Black or African American","Black People"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-19T01:25:55.794583Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}