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Incubation of large unilamellar liposomes with mice brain cytosol led to massive formation of small vesicles, whereas cytosol of amphiphysin 1 knockout mice was much less efficient in this reaction. Vesicle formation from large liposomes by purified dynamin was also strongly enhanced by amphiphysin. In the presence of liposomes, amphiphysin strongly affected dynamin GTPase activity and the recruitment of dynamin to the liposomes, but this activity was highly dependent on liposome size. Deletion from amphiphysin of its central proline-rich stretch dramatically potentiated its effect on dynamin, possibly by relieving an inhibitory intramolecular interaction. These results suggest a model in which maturation of endocytic pits correlates with the oligomerization of dynamin with either amphiphysin or other proteins with similar domain structure. Formation of these complexes is coupled to the activation of dynamin GTPase activity, thus explaining how deep invagination of the pit leads to fission.","is_dataset_classified":null,"base_score":4.795790545596741,"endowment":4.795790545596741,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15318165","pmcid":"PMC516627","openalex_id":"https://openalex.org/W2164142139","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"NS 36251","title":null},{"funder_name":"Telethon","grant_id":"D.111","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R37 NS036251","title":null},{"funder_name":"NCI NIH HHS","grant_id":"CA46128","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P01 CA046128","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS036251","title":null}],"total_grants":6,"fwci":3.1065,"citation_percentile":0.91674183,"influential_citations":5,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":8},{"year":2014,"count":2},{"year":2015,"count":3},{"year":2016,"count":2},{"year":2017,"count":6},{"year":2018,"count":7},{"year":2019,"count":4},{"year":2021,"count":7},{"year":2022,"count":6},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"bronze","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.emboj.7600355","host_type":"journal"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC516627","host_type":"GREEN"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.emboj.7600355","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Fsj.emboj.7600355","host_type":"publisher"},{"url":"https://link.springer.com/content/pdf/10.1038/sj.emboj.7600355.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1038/sj.emboj.7600355","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full/10.1038/sj.emboj.7600355","host_type":"publisher"},{"url":"https://doi.org/10.1038/sj.emboj.7600355","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15318165","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/516627","host_type":"repository"}],"fields_of_study":["Cellular transport and secretion","Lipid Membrane Structure and Behavior","Alzheimer's disease research and treatments","Biology","Medicine","Chemistry","Animals","Brain","Cattle","Clathrin-Coated Vesicles","Cytosol","Dynamins","Endocytosis","In Vitro Techniques","Lipid Bilayers","Liposomes","Mice","Mice, Knockout","Models, Biological","Nerve Tissue Proteins","Particle Size","Protein Structure, Tertiary"],"mesh_terms":["Animals","Brain","Cattle","Cytosol","Endocytosis","Lipid Bilayers","Liposomes","Models, Biological","Nerve Tissue Proteins","Particle Size","Protein Structure, Tertiary","Mice, Knockout","Clathrin-Coated Vesicles","Dynamins","Mice","In Vitro Techniques"],"keywords":["Amphiphysin","Dynamin","Liposome","Endocytosis","Endocytic cycle","Chemistry","GTPase","Cell biology","Biophysics","Internalization","Synaptic vesicle recycling","Vesicle","Cytosol","Biochemistry","Synaptic vesicle","Biology","Membrane","Receptor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T09:09:31.697186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}