{"doi":"10.1038/sj.emboj.7600020","title":"Blocking HIV‐1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor","abstract":null,"journal":"The EMBO Journal","year":2004,"id":614794,"datarank":0.6515708132780527,"base_score":4.343805421853684,"endowment":4.343805421853684,"self_citation_contribution":0.6515708132780527,"citation_network_contribution":0.0,"self_endowment_contribution":0.6515708132780527,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":76,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":676600,"name":"Gustavo del Real","orcid":"0000-0002-8171-2274","position":1,"is_corresponding":false},{"id":204248,"name":"Antonio Serrano","orcid":null,"position":2,"is_corresponding":false},{"id":1584331,"name":"Patricia Hernanz‐Falcón","orcid":null,"position":3,"is_corresponding":false},{"id":1584332,"name":"Silvia F Soriano","orcid":null,"position":4,"is_corresponding":false},{"id":1584333,"name":"Antonio J Vila‐Coro","orcid":null,"position":5,"is_corresponding":false},{"id":1584334,"name":"Ana Martín de Ana","orcid":null,"position":6,"is_corresponding":false},{"id":1584335,"name":"Pilar Lucas","orcid":null,"position":7,"is_corresponding":false},{"id":1584336,"name":"Ignacio Prieto","orcid":null,"position":8,"is_corresponding":false},{"id":606847,"name":"Carlos Martínez‐A","orcid":"0000-0002-2121-189X","position":9,"is_corresponding":false},{"id":576295,"name":"Mario Mellado","orcid":"0000-0001-6325-1630","position":10,"is_corresponding":false},{"id":1584330,"name":"José Miguel Rodríguez‐Frade","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Blocking HIV‐1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor","abstract":"The identification of chemokine receptors as HIV-1 coreceptors has focused research on developing strategies to prevent HIV-1 infection. We generated CCR2-01, a CCR2 receptor-specific monoclonal antibody that neither competes with the chemokine CCL2 for binding nor triggers signaling, but nonetheless blocks replication of monotropic (R5) and T-tropic (X4) HIV-1 strains. This effect is explained by the ability of CCR2-01 to induce oligomerization of CCR2 with the CCR5 or CXCR4 viral coreceptors. HIV-1 infection through CCR5 and CXCR4 receptors can thus be prevented in the absence of steric hindrance or receptor downregulation by acting in trans on a receptor that is rarely used by the virus to infect cells.","is_dataset_classified":null,"base_score":4.343805421853684,"endowment":4.343805421853684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"14685276","pmcid":"PMC1271658","openalex_id":"https://openalex.org/W2127492591","authors":[],"funders":[],"total_grants":0,"fwci":1.4619,"citation_percentile":0.79775281,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":6},{"year":2014,"count":2},{"year":2015,"count":3},{"year":2016,"count":2},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2023,"count":2},{"year":2025,"count":4}],"oa_status":"green","license":"https://www.springernature.com/gp/researchers/text-and-data-mining","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1271658","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1271658","host_type":"repository"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Fsj.emboj.7600020","host_type":"publisher"},{"url":"https://link.springer.com/content/pdf/10.1038/sj.emboj.7600020.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1038/sj.emboj.7600020","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full/10.1038/sj.emboj.7600020","host_type":"publisher"},{"url":"https://doi.org/10.1038/sj.emboj.7600020","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/14685276","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC1271658","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","Immune Cell Function and Interaction","T-cell and B-cell Immunology","Amino Acid Substitution","Antibodies, Monoclonal","Blotting, Western","Calcium","Cell Line","Chemokine CCL2","Chemokines, CC","Chemotaxis","Culture Media, Serum-Free","Dimerization","Down-Regulation","Electrophoresis, Polyacrylamide Gel","Flow Cytometry","Genes, Reporter","HIV Infections","HIV-1","Humans","Isoleucine","Kinetics","Ligands","Monocytes","Precipitin Tests","Receptors, CCR5","Receptors, CXCR4","Receptors, Chemokine","Reverse Transcriptase Polymerase Chain Reaction"],"mesh_terms":["Antibodies, Monoclonal","Calcium","Cell Line","Chemotaxis","Electrophoresis, Polyacrylamide Gel","Flow Cytometry","Humans","Isoleucine","Kinetics","Ligands","Monocytes","Precipitin Tests","Blotting, Western","HIV-1","Down-Regulation","HIV Infections","Culture Media, Serum-Free","Genes, Reporter","Chemokine CCL2","Dimerization","Receptors, Chemokine","Receptors, CCR5","Receptors, CXCR4","Chemokines, CC","Amino Acid Substitution","Reverse Transcriptase Polymerase Chain Reaction"],"keywords":["Humanities","Library science","Art","Computer science"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T17:06:09.067416Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}