{"doi":"10.1038/sj.cdd.4401559","title":"Daxx is required for stress-induced cell death and JNK activation","abstract":null,"journal":"Cell Death & Differentiation","year":2005,"id":615619,"datarank":0.6782682865573562,"base_score":4.5217885770490405,"endowment":4.5217885770490405,"self_citation_contribution":0.6782682865573562,"citation_network_contribution":0.0,"self_endowment_contribution":0.6782682865573562,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":91,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1586883,"name":"M Stagno D'Alcontres","orcid":null,"position":1,"is_corresponding":false},{"id":1586884,"name":"P Salomoni","orcid":null,"position":2,"is_corresponding":false},{"id":1586882,"name":"A F Khelifi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Daxx is required for stress-induced cell death and JNK activation","abstract":"Daxx has been implicated in the modulation of apoptosis in response to various stimuli. In the nucleus, Daxx interacts and colocalizes with the promyelocytic leukemia protein (PML) into the PML-nuclear body. Moreover, overexpressed Daxx positively modulates FAS-ligand and TGFbeta-induced apoptosis. However, recent reports indicate that Daxx can also act as an antiapoptotic factor. As most studies on the role of Daxx in cell death have been conducted using tumour cell lines, we analysed the function of Daxx in physiological settings. We found that Daxx is induced upon exposure to ultraviolet (UV) irradiation and hydrogen peroxide treatment. We employed RNA interference to downregulate Daxx in primary fibroblasts. Remarkably, Daxx-depleted cells are resistant to cell death induced by both UV irradiation and oxidative stress. Furthermore, the downregulation of Daxx results in impaired MKK/c-Jun-N-terminal kinase (JNK) activation. This is the first evidence that Daxx promotes cell death and JNK activation in physiological conditions.","is_dataset_classified":null,"base_score":4.5217885770490405,"endowment":4.5217885770490405,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15861194","pmcid":null,"openalex_id":"https://openalex.org/W1992749833","authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"MC_U132670601","title":null}],"total_grants":1,"fwci":2.8475,"citation_percentile":0.90689647,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":7},{"year":2014,"count":5},{"year":2015,"count":3},{"year":2016,"count":4},{"year":2017,"count":1},{"year":2018,"count":3},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":4},{"year":2022,"count":1},{"year":2023,"count":4},{"year":2024,"count":1},{"year":2025,"count":6},{"year":2026,"count":2}],"oa_status":"closed","license":"http://www.springer.com/tdm","oa_locations":[{"url":"http://www.nature.com/articles/4401559.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/4401559","host_type":"publisher"},{"url":"https://doi.org/10.1038/sj.cdd.4401559","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15861194","host_type":"repository"},{"url":"http://discovery.ucl.ac.uk/113774/","host_type":"repository"}],"fields_of_study":["Retinoids in leukemia and cellular processes","Cell death mechanisms and regulation","RNA Interference and Gene Delivery","Adaptor Proteins, Signal Transducing","Carrier Proteins","Caspases","Cell Death","Cell Nucleus","Cell Proliferation","Cell Survival","Cells, Cultured","Co-Repressor Proteins","DNA Damage","Down-Regulation","Enzyme Activation","Fibroblasts","Humans","Hydrogen Peroxide","Intracellular Signaling Peptides and Proteins","JNK Mitogen-Activated Protein Kinases","MAP Kinase Kinase Kinase 5","Molecular Chaperones","Nuclear Proteins","Oxidants","Oxidative Stress","Protein Transport","Proto-Oncogene Proteins c-bcl-2","RNA Interference","Signal Transduction","Tumor Suppressor Protein p53","Ultraviolet Rays"],"mesh_terms":["Carrier Proteins","Cell Nucleus","Cell Survival","Cells, Cultured","DNA Damage","Enzyme Activation","Fibroblasts","Humans","Hydrogen Peroxide","Nuclear Proteins","Ultraviolet Rays","Signal Transduction","Down-Regulation","Tumor Suppressor Protein p53","Oxidants","Cell Death","Oxidative Stress","Molecular Chaperones","Proto-Oncogene Proteins c-bcl-2","Caspases","Protein Transport","RNA Interference","Intracellular Signaling Peptides and Proteins","JNK Mitogen-Activated Protein Kinases","MAP Kinase Kinase Kinase 5","Adaptor Proteins, Signal Transducing","Cell Proliferation","Co-Repressor Proteins"],"keywords":["Death-associated protein 6","Programmed cell death","Promyelocytic leukemia protein","Downregulation and upregulation","Cell biology","Apoptosis","Cancer research","Chemistry","Nuclear protein","Biology","Transcription factor","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T20:35:30.351375Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}