{"doi":"10.1038/sj.bjp.0705900","title":"The melanocortin receptor subtypes in chicken have high preference to ACTH‐derived peptides","abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Melanocortin (MC) receptors are widely distributed throughout the body of chicken, like in mammals, and participate in a wide range of physiological functions.</jats:p></jats:list-item>\n<jats:list-item><jats:p>To clarify the pharmacological impact of ligands acting in the MC system, we expressed the chicken MC1, MC2, MC3, MC4 and MC5 (cMC1–5) receptors in eukaryotic cells and performed comprehensive pharmacological characterization of the potency of endogenous and synthetic melanocortin peptides.</jats:p></jats:list-item>\n<jats:list-item><jats:p>Remarkably, the cMC receptors displayed high affinity for ACTH‐derived peptides and in general low affinity for <jats:italic>α</jats:italic>‐MSH. It is evident that not only the cMC2 receptor but also the other cMC receptors interact with ACTH‐derived peptide through an epitope beyond the sequence of <jats:italic>α</jats:italic>‐MSH.</jats:p></jats:list-item>\n<jats:list-item><jats:p>The synthetic ligand MTII was found to be a potent agonist whereas HS024 was a potent antagonist at the cMC4 receptor, indicating that these ligands are suitable for physiological studies in chicken.</jats:p></jats:list-item>\n<jats:list-item><jats:p>We also show the presence of prohormone convertase 1 (PC1) and PC2 genes in chicken, and that these peptides are coexpressed with proopiomelanocortin (POMC) in various tissues.</jats:p></jats:list-item>\n</jats:list>\n</jats:p><jats:p><jats:italic>British Journal of Pharmacology</jats:italic> (2004) <jats:bold>143</jats:bold>, 626–637. doi:<jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038/sj.bjp.0705900\">10.1038/sj.bjp.0705900</jats:ext-link></jats:p>","journal":"British Journal of Pharmacology","year":2004,"id":651046,"datarank":0.635115975689589,"base_score":4.23410650459726,"endowment":4.23410650459726,"self_citation_contribution":0.635115975689589,"citation_network_contribution":0.0,"self_endowment_contribution":0.635115975689589,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":68,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1697807,"name":"Eri Hotta","orcid":null,"position":1,"is_corresponding":false},{"id":1697808,"name":"Zuzana Kilianova","orcid":null,"position":2,"is_corresponding":false},{"id":1060708,"name":"Tatjana Haitina","orcid":"0000-0002-8754-5534","position":3,"is_corresponding":false},{"id":1697809,"name":"Aneta Ringholm","orcid":null,"position":4,"is_corresponding":false},{"id":1697810,"name":"Lisa Johansson","orcid":null,"position":5,"is_corresponding":false},{"id":1697811,"name":"Nicole Gallo‐Payet","orcid":null,"position":6,"is_corresponding":false},{"id":1697812,"name":"Sakae Takeuchi","orcid":null,"position":7,"is_corresponding":false},{"id":1697813,"name":"Helgi B Schiöth","orcid":null,"position":8,"is_corresponding":false},{"id":1697806,"name":"Maria K Ling","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The melanocortin receptor subtypes in chicken have high preference to ACTH‐derived peptides","abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Melanocortin (MC) receptors are widely distributed throughout the body of chicken, like in mammals, and participate in a wide range of physiological functions.</jats:p></jats:list-item>\n<jats:list-item><jats:p>To clarify the pharmacological impact of ligands acting in the MC system, we expressed the chicken MC1, MC2, MC3, MC4 and MC5 (cMC1–5) receptors in eukaryotic cells and performed comprehensive pharmacological characterization of the potency of endogenous and synthetic melanocortin peptides.</jats:p></jats:list-item>\n<jats:list-item><jats:p>Remarkably, the cMC receptors displayed high affinity for ACTH‐derived peptides and in general low affinity for <jats:italic>α</jats:italic>‐MSH. It is evident that not only the cMC2 receptor but also the other cMC receptors interact with ACTH‐derived peptide through an epitope beyond the sequence of <jats:italic>α</jats:italic>‐MSH.</jats:p></jats:list-item>\n<jats:list-item><jats:p>The synthetic ligand MTII was found to be a potent agonist whereas HS024 was a potent antagonist at the cMC4 receptor, indicating that these ligands are suitable for physiological studies in chicken.</jats:p></jats:list-item>\n<jats:list-item><jats:p>We also show the presence of prohormone convertase 1 (PC1) and PC2 genes in chicken, and that these peptides are coexpressed with proopiomelanocortin (POMC) in various tissues.</jats:p></jats:list-item>\n</jats:list>\n</jats:p><jats:p><jats:italic>British Journal of Pharmacology</jats:italic> (2004) <jats:bold>143</jats:bold>, 626–637. doi:<jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038/sj.bjp.0705900\">10.1038/sj.bjp.0705900</jats:ext-link></jats:p>","is_dataset_classified":null,"base_score":4.23410650459726,"endowment":4.23410650459726,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15466451","pmcid":"PMC1575423","openalex_id":"https://openalex.org/W2141240322","authors":[],"funders":[],"total_grants":0,"fwci":1.1751,"citation_percentile":0.7565388,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":5},{"year":2014,"count":7},{"year":2015,"count":3},{"year":2016,"count":4},{"year":2017,"count":7},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":6},{"year":2022,"count":1},{"year":2024,"count":2},{"year":2025,"count":2}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0705900","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0705900","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Fsj.bjp.0705900","host_type":"publisher"},{"url":"https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1038/sj.bjp.0705900","host_type":"publisher"},{"url":"https://doi.org/10.1038/sj.bjp.0705900","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15466451","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1575423","host_type":"repository"}],"fields_of_study":["Regulation of Appetite and Obesity","Biochemical Analysis and Sensing Techniques","melanin and skin pigmentation","Adrenocorticotropic Hormone","Animals","Binding, Competitive","Cell Line","Chickens","Cloning, Molecular","Cyclic AMP","Humans","Kinetics","Peptides","Phylogeny","Pro-Opiomelanocortin","Proprotein Convertase 1","Proprotein Convertase 2","Radioligand Assay","Receptors, Melanocortin","Reverse Transcriptase Polymerase Chain Reaction","Tissue Distribution","Transfection","alpha-MSH"],"mesh_terms":["Cyclic AMP","Adrenocorticotropic Hormone","alpha-MSH","Animals","Binding, Competitive","Cell Line","Chickens","Cloning, Molecular","Humans","Kinetics","Peptides","Phylogeny","Pro-Opiomelanocortin","Radioligand Assay","Tissue Distribution","Transfection","Reverse Transcriptase Polymerase Chain Reaction","Receptors, Melanocortin","Proprotein Convertase 1","Proprotein Convertase 2"],"keywords":["Melanocortin","Melanocortin 3 receptor","Melanocortin receptor","Receptor","Proopiomelanocortin","ACTH receptor","Melanocortins","Agonist","Chemistry","Endocrinology","Partial agonist","Internal medicine","Biochemistry","Biology","Adrenocorticotropic hormone","Hormone"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T06:33:20.120293Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}