{"doi":"10.1038/sj.bjc.6604208","title":"G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer","abstract":null,"journal":"British Journal of Cancer","year":2008,"id":621232,"datarank":0.8812396096278047,"base_score":5.87493073085203,"endowment":5.87493073085203,"self_citation_contribution":0.8812396096278047,"citation_network_contribution":0.0,"self_endowment_contribution":0.8812396096278047,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":355,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":6,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1604001,"name":"C D Britten","orcid":null,"position":1,"is_corresponding":false},{"id":1604000,"name":"N Bucher","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer","abstract":"Rigorous quality control steps, termed checkpoints, tightly regulate progression through the cell cycle. DNA-damaging chemotherapy and radiation activate functional cellular checkpoints. These checkpoints can facilitate DNA repair and promote cell death in unrepaired cells. There are at least three DNA damage checkpoints - at G1/S, S, and G2/M - as well as a mitotic spindle checkpoint. Most cancer cells harbour mutations in tumour suppressors and/or oncogenes, which impair certain cell checkpoints. Inhibiting the remaining cell checkpoints - particularly after exposure of cancer cells to chemotherapy and/or radiation - allows cell death, a strategy now being employed in cancer therapeutics. With our increasing knowledge of cell cycle regulation, many compounds have been developed to inhibit specific checkpoint components, particularly at the G2/M transition. One such target is checkpoint kinase-1 (Chk1). We review here the molecular framework of the cell cycle, the rationale for targeting Chk1, the preclinical concepts related to the development of Chk1 inhibitors, and the efficacy and safety results from Chk1 inhibitors now in phase I/II trials.","is_dataset_classified":null,"base_score":5.87493073085203,"endowment":5.87493073085203,"datacite_reuse_total":6,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18231106","pmcid":"PMC2243162","openalex_id":"https://openalex.org/W2023942118","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"T32 HL066992","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"T32 HL 66992","title":null}],"total_grants":2,"fwci":11.3182,"citation_percentile":0.99064697,"influential_citations":0,"citation_trend":[{"year":2012,"count":35},{"year":2013,"count":29},{"year":2014,"count":23},{"year":2015,"count":14},{"year":2016,"count":14},{"year":2017,"count":18},{"year":2018,"count":12},{"year":2019,"count":9},{"year":2020,"count":15},{"year":2021,"count":21},{"year":2022,"count":19},{"year":2023,"count":30},{"year":2024,"count":17},{"year":2025,"count":10},{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by-nc-sa","oa_locations":[{"url":"https://www.nature.com/articles/6604208.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/6604208.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/6604208.pdf","host_type":"publisher"},{"url":"http://www.nature.com/articles/6604208","host_type":"publisher"},{"url":"https://doi.org/10.1038/sj.bjc.6604208","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18231106","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2243162","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC2243162","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC2243162?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["DNA Repair Mechanisms","Cancer-related Molecular Pathways","Microtubule and mitosis dynamics","Antineoplastic Agents","Cell Cycle","Checkpoint Kinase 1","DNA Damage","DNA Repair","G2 Phase","Humans","Neoplasms","Protein Kinase Inhibitors","Protein Kinases"],"mesh_terms":["Checkpoint Kinase 1","Antineoplastic Agents","Cell Cycle","DNA Damage","DNA Repair","Humans","Neoplasms","Protein Kinases","G2 Phase","Protein Kinase Inhibitors"],"keywords":["CHEK1","G2-M DNA damage checkpoint","Cell cycle checkpoint","DNA damage","DNA repair","Cell cycle","Cancer research","Mitotic catastrophe","Mitosis","Cancer cell","Spindle checkpoint","Biology","Cancer","Cell biology","Checkpoint Kinase 2","Cell","DNA","Genetics","Cell division","Spindle apparatus"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.24186137.v1","title":"Additional file 1 of Small molecule targeting of the p38/Mk2 stress signaling pathways to improve cancer treatment","publisher":"figshare","resource_type":"Presentation"},{"doi":"10.6084/m9.figshare.24186137","title":"Additional file 1 of Small molecule targeting of the p38/Mk2 stress signaling pathways to improve cancer treatment","publisher":"figshare","resource_type":"Presentation"},{"doi":"10.6084/m9.figshare.22612751.v1","title":"Additional file 1 of Transcriptome analysis of gene expression profiling from the deep sea in situ to the laboratory for the cold seep mussel Gigantidas haimaensis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.22612751","title":"Additional file 1 of Transcriptome analysis of gene expression profiling from the deep sea in situ to the laboratory for the cold seep mussel Gigantidas haimaensis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.22612754.v1","title":"Additional file 2 of Transcriptome analysis of gene expression profiling from the deep sea in situ to the laboratory for the cold seep mussel Gigantidas haimaensis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.22612754","title":"Additional file 2 of Transcriptome analysis of gene expression profiling from the deep sea in situ to the laboratory for the cold seep mussel Gigantidas haimaensis","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T13:45:10.844039Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}