{"doi":"10.1038/s44172-024-00167-7","title":"A dual-channel visible light optical coherence tomography system enables wide-field, full-range, and shot-noise limited human retinal imaging","abstract":"Abstract Visible light optical coherence tomography (VIS-OCT) is an emerging ophthalmic imaging method featuring ultrahigh depth resolution, retinal microvascular oximetry, and distinct scattering contrast in the visible spectral range. The clinical utility of VIS-OCT is hampered by the fundamental trade-off between the imaging depth range and axial resolution, which are determined by the spectral resolution and bandwidth, respectively. To address this trade-off, here we developed a dual-channel VIS-OCT system with three major advancements including the first linear-in-K VIS-OCT spectrometer to decrease the roll-off, reference pathlength modulation to expand the imaging depth range, and per-A-line noise cancellation to remove excess noise, Due to these unique designs, this system achieves 7.2 dB roll-off over the full 1.74 mm depth range (water) with shot-noise limited performance. The system uniquely enables >60° wide-field imaging which would allow simultaneous imaging of the peripheral retina and optic nerve head, as well as ultrahigh 1.3 µm depth resolution (water). Benefiting from the additional near-infrared (NIR) channel of the dual-channel design, this system is compatible with Doppler OCT and OCT angiography (OCTA). The comprehensive structure-function measurement enabled by this dual-channel VIS-OCT system is an advance towards adoption of VIS-OCT in clinical applications.","journal":"Communications Engineering","year":2024,"id":421779,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":988251,"name":"Stephanie Nolen","orcid":"0000-0002-0151-5669","position":1,"is_corresponding":false},{"id":323158,"name":"Weiye Song","orcid":"0000-0002-1835-9770","position":2,"is_corresponding":false},{"id":323159,"name":"Wenjun Shao","orcid":"0000-0003-0945-882X","position":3,"is_corresponding":false},{"id":323160,"name":"Wei Yi","orcid":"0000-0003-4303-967X","position":4,"is_corresponding":false},{"id":382741,"name":"Amir H. Kashani","orcid":"0000-0001-9767-7920","position":5,"is_corresponding":false},{"id":323164,"name":"Ji Yi","orcid":"0000-0001-6583-7192","position":6,"is_corresponding":false},{"id":970158,"name":"Jingyu Wang","orcid":"0000-0002-1614-4426","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T01:57:41.370244Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}