{"doi":"10.1038/s43587-024-00639-7","title":"A plasma protein-based risk score to predict hip fractures","abstract":"As there are effective treatments to reduce hip fractures, identification of patients at high risk of hip fracture is important to inform efficient intervention strategies. To obtain a new tool for hip fracture prediction, we developed a protein-based risk score in the Cardiovascular Health Study using an aptamer-based proteomic platform. The proteomic risk score predicted incident hip fractures and improved hip fracture discrimination in two Trøndelag Health Study validation cohorts using the same aptamer-based platform. When transferred to an antibody-based proteomic platform in a UK Biobank validation cohort, the proteomic risk score was strongly associated with hip fractures (hazard ratio per s.d. increase, 1.64; 95% confidence interval 1.53-1.77). The proteomic risk score, but not available polygenic risk scores for fractures or bone mineral density, improved the C-index beyond the fracture risk assessment tool (FRAX), which integrates information from clinical risk factors (C-index, FRAX 0.735 versus FRAX + proteomic risk score 0.776). The developed proteomic risk score constitutes a new tool for stratifying patients according to hip fracture risk; however, its improvement in hip fracture discrimination is modest and its clinical utility beyond FRAX with information on femoral neck bone mineral density remains to be determined.","journal":"Nature Aging","year":2024,"id":427772,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":304548,"name":"Maria Nethander","orcid":"0000-0003-3688-906X","position":1,"is_corresponding":false},{"id":607983,"name":"Howard A Fink","orcid":"0000-0002-5985-5447","position":2,"is_corresponding":false},{"id":1228503,"name":"Anna E. Törnqvist","orcid":"0000-0003-2621-9038","position":3,"is_corresponding":false},{"id":232869,"name":"Diana Jalal","orcid":"0000-0002-1975-8650","position":4,"is_corresponding":false},{"id":449335,"name":"Petra Bůžková","orcid":"0000-0001-8299-4974","position":5,"is_corresponding":false},{"id":738638,"name":"Joshua I. Barzilay","orcid":"0000-0001-7044-4166","position":6,"is_corresponding":false},{"id":504749,"name":"Laura Carbone","orcid":"0000-0003-1007-5949","position":7,"is_corresponding":false},{"id":14730,"name":"Maiken E. Gabrielsen","orcid":"0000-0002-7132-5633","position":8,"is_corresponding":false},{"id":1051865,"name":"Louise Grahnemo","orcid":"0000-0001-5276-6612","position":9,"is_corresponding":false},{"id":269890,"name":"Tianyuan Lu","orcid":"0000-0002-5664-5698","position":10,"is_corresponding":false},{"id":262547,"name":"Kristian Hveem","orcid":"0000-0001-8157-9744","position":11,"is_corresponding":false},{"id":316761,"name":"Christian Jonasson","orcid":"0000-0002-7694-6025","position":12,"is_corresponding":false},{"id":246786,"name":"Jorge R. Kizer","orcid":"0000-0001-9936-7803","position":13,"is_corresponding":false},{"id":347014,"name":"Arnulf Langhammer","orcid":"0000-0001-5296-6673","position":14,"is_corresponding":false},{"id":291349,"name":"Kenneth J. Mukamal","orcid":"0000-0001-8450-6970","position":15,"is_corresponding":false},{"id":268751,"name":"Robert E. Gerszten","orcid":"0000-0002-6767-7687","position":16,"is_corresponding":false},{"id":17625,"name":"Bruce M. Psaty","orcid":"0000-0002-7278-2190","position":17,"is_corresponding":false},{"id":598474,"name":"John A. Robbins","orcid":"0000-0002-8937-9613","position":18,"is_corresponding":false},{"id":22017,"name":"Yan V. Sun","orcid":"0000-0002-2838-1824","position":19,"is_corresponding":false},{"id":14668,"name":"Anne Heidi Skogholt","orcid":"0000-0001-7466-0405","position":20,"is_corresponding":false},{"id":86236,"name":"John А. Kanis","orcid":"0000-0002-3129-4326","position":21,"is_corresponding":false},{"id":304551,"name":"Helena Johansson","orcid":"0000-0002-7720-9297","position":22,"is_corresponding":false},{"id":50530,"name":"Bjørn Olav Åsvold","orcid":"0000-0003-3837-2101","position":23,"is_corresponding":false},{"id":342254,"name":"Rodrigo J. Valderrábano","orcid":"0000-0002-4910-3997","position":24,"is_corresponding":false},{"id":78817,"name":"Jie Zheng","orcid":"0000-0002-6623-6839","position":25,"is_corresponding":false},{"id":37303,"name":"J. Brent Richards","orcid":"0000-0002-3746-9086","position":26,"is_corresponding":false},{"id":850151,"name":"Eivind Coward","orcid":null,"position":27,"is_corresponding":false},{"id":21920,"name":"Claes Ohlsson","orcid":"0000-0002-9633-2805","position":28,"is_corresponding":false},{"id":276456,"name":"Thomas R. Austin","orcid":null,"position":0,"is_corresponding":true}],"reference_count":72,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:58:52.576447Z","pmid":"38802582","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}