{"doi":"10.1038/s43587-021-00129-0","title":"Bifidobacterium adolescentis regulates catalase activity and host metabolism and improves healthspan and lifespan in multiple species","abstract":"To identify candidate bacteria associated with aging, we performed fecal microbiota sequencing in young, middle-aged and older adults, and found lower Bifidobacterium adolescentis abundance in older individuals aged ≥60 years. Dietary supplementation of B. adolescentis improved osteoporosis and neurodegeneration in a mouse model of premature aging (Terc<sup>-/-</sup>) and increased healthspan and lifespan in Drosophila melanogaster and Caenorhabditis elegans. B. adolescentis supplementation increased the activity of the catalase (CAT) enzyme in skeletal muscle and brain tissue from Terc<sup>-/-</sup> mice, and suppressed cellular senescence in mouse embryonic fibroblasts. Transgenic deletion of catalase (ctl-2) in C. elegans abolished the effects of B. adolescentis on the lifespan and healthspan. B. adolescentis feeding also led to changes in oxidative stress-associated metabolites in Terc<sup>-/-</sup> mouse feces. These results suggest a role for B. adolescentis in improving the healthspan and lifespan through the regulation of CAT activity and host metabolism.","journal":"Nature Aging","year":2021,"id":8175,"datarank":0.5926865577872142,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"self_citation_contribution":0.5926865577872142,"citation_network_contribution":0.0,"self_endowment_contribution":0.5926865577872142,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0437,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-11-16","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":31209,"name":"Luyi Chen","orcid":"0000-0002-5023-5858","position":1,"is_corresponding":false},{"id":31204,"name":"Yadong Qi","orcid":"0000-0002-6819-5903","position":2,"is_corresponding":false},{"id":31210,"name":"Jilei Xu","orcid":null,"position":3,"is_corresponding":false},{"id":31207,"name":"Qiwei Ge","orcid":"0000-0003-1689-6836","position":4,"is_corresponding":false},{"id":72356,"name":"Yuedan Fan","orcid":null,"position":5,"is_corresponding":false},{"id":72357,"name":"Du Chen","orcid":null,"position":6,"is_corresponding":false},{"id":31206,"name":"Yawen Zhang","orcid":"0000-0003-0193-094X","position":7,"is_corresponding":false},{"id":31211,"name":"Lan Wang","orcid":"0000-0001-7394-4684","position":8,"is_corresponding":false},{"id":31216,"name":"Tongyao Hou","orcid":"0000-0001-6009-2822","position":9,"is_corresponding":false},{"id":72358,"name":"Xiaohang Yang","orcid":"0000-0001-5192-5706","position":10,"is_corresponding":false},{"id":72359,"name":"Yongmei Xi","orcid":"0000-0001-7374-2564","position":11,"is_corresponding":false},{"id":31217,"name":"Jianmin Si","orcid":"0000-0001-6257-2512","position":12,"is_corresponding":false},{"id":37238,"name":"Lijun Kang","orcid":"0000-0002-2490-5360","position":13,"is_corresponding":false},{"id":31219,"name":"Liangjing Wang","orcid":"0000-0001-8227-8855","position":14,"is_corresponding":false},{"id":72360,"name":"Chen Du","orcid":"0000-0003-1435-5390","position":15,"is_corresponding":false},{"id":31218,"name":"Shujie Chen","orcid":"0000-0001-5099-5569","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}