{"doi":"10.1038/s42255-024-01018-7","title":"Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans","abstract":"Metformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce blood glucose levels and suppress appetite. Here we report a significant elevation of the appetite-suppressing metabolite N-lactoyl phenylalanine (Lac-Phe) in the blood of individuals treated with metformin across seven observational and interventional studies. Furthermore, Lac-Phe levels were found to rise in response to acute metformin administration and post-prandially in patients with T2D or in metabolically healthy volunteers.","journal":"Nature Metabolism","year":2024,"id":417111,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":81,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":642549,"name":"Emily A. Day","orcid":"0000-0003-3245-5715","position":1,"is_corresponding":false},{"id":1202523,"name":"Katie O’Brien","orcid":"0000-0002-2414-635X","position":2,"is_corresponding":false},{"id":1024591,"name":"John Scanlan","orcid":"0009-0001-9559-4731","position":3,"is_corresponding":false},{"id":1203336,"name":"Grace Cromwell","orcid":null,"position":4,"is_corresponding":false},{"id":60334,"name":"Aine Ni Scannail","orcid":null,"position":5,"is_corresponding":false},{"id":716574,"name":"Marie E. McDonnell","orcid":"0000-0002-2263-9783","position":6,"is_corresponding":false},{"id":476671,"name":"David K. Finlay","orcid":"0000-0003-2716-6679","position":7,"is_corresponding":false},{"id":85084,"name":"Lydia Lynch","orcid":"0000-0002-4273-4681","position":8,"is_corresponding":false},{"id":1202522,"name":"Barry Scott","orcid":"0000-0002-8841-3525","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T01:56:50.743370Z","pmid":"38499765","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}