{"doi":"10.1038/s42003-025-08231-4","title":"Structural-functional brain network coupling during cognitive demand reveals intelligence-relevant communication strategies","abstract":"Abstract Intelligence is a broad mental capability influencing human performance across tasks. Individual differences in intelligence have been linked to characteristics of structural and functional brain networks. Here, we consider their alignment, the structural-functional brain network coupling (SC-FC coupling) during resting state and during active cognition, to predict general intelligence. Using diffusion-weighted and functional magnetic resonance imaging data from 764 participants of the Human Connectome Project (replication: N 1 = 126, N 2 = 180), we model SC-FC coupling with similarity and communication measures that capture functional interactions unfolding on top of structural brain networks. By accounting for variations in brain region-specific neural signaling strategies, we show that individual differences in SC-FC coupling patterns predict individual intelligence scores. Most robust predictions result from cognitively demanding tasks and task combinations. Our study suggests the existence of an intrinsic SC-FC coupling organization enabling fine-drawn intelligence-relevant adaptations that support efficient information processing by facilitating brain region-specific adjustment to external task demands.","journal":"Communications Biology","year":2025,"id":512561,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":666786,"name":"Jonas A. Thiele","orcid":"0000-0003-2702-9690","position":1,"is_corresponding":false},{"id":279196,"name":"Joshua Faskowitz","orcid":"0000-0003-1814-7206","position":2,"is_corresponding":false},{"id":267220,"name":"Caio Seguin","orcid":"0000-0001-9384-6336","position":3,"is_corresponding":false},{"id":63294,"name":"Olaf Sporns","orcid":"0000-0001-7265-4036","position":4,"is_corresponding":false},{"id":666787,"name":"Kirsten Hilger","orcid":"0000-0003-3940-5884","position":5,"is_corresponding":false},{"id":1162469,"name":"Johanna L. Popp","orcid":"0000-0003-1704-9890","position":0,"is_corresponding":true}],"reference_count":110,"raw_metadata":null,"created_at":"2026-07-19T02:48:06.263458Z","pmid":"40467962","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}