{"doi":"10.1038/s42003-025-07484-3","title":"Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke","abstract":null,"journal":"Communications Biology","year":2025,"id":644524,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":526755,"name":"Ashley J. Smuder","orcid":"0000-0001-5437-3097","position":1,"is_corresponding":false},{"id":1677666,"name":"Bryce J. Gambino","orcid":null,"position":2,"is_corresponding":false},{"id":1464083,"name":"Cristina Delgado","orcid":"0009-0005-0551-8479","position":3,"is_corresponding":false},{"id":1677669,"name":"Michael T. Rua","orcid":null,"position":4,"is_corresponding":false},{"id":728549,"name":"Ryan N. Montalvo","orcid":"0000-0002-0323-4545","position":5,"is_corresponding":false},{"id":1677673,"name":"Finleigh P. Fitton","orcid":null,"position":6,"is_corresponding":false},{"id":1677674,"name":"Deborah A. Morse","orcid":null,"position":7,"is_corresponding":false},{"id":461302,"name":"Thomas L. Clanton","orcid":"0000-0003-0600-7150","position":8,"is_corresponding":false},{"id":747875,"name":"Jamal M. Alzahrani","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke","abstract":"As global temperatures rise, heat-related chronic health disorders are predicted to become more prevalent. We tested whether a single exposure to acute heat illness, using a preclinical mouse model of exertional heat stroke (EHS), can induce late-emerging health disorders that progress into chronic disease. Following EHS, mice were followed for 3 months; after two weeks of recovery, half were placed on a Western diet to determine if previous EHS exposure amplifies the negative consequences of an atherogenic diet. When compared to sham exercise controls, EHS-exposed mice exhibit accelerated diet-induced obesity, develop low level cardiac hypertrophy, develop accelerated diet-induced liver steatosis, severe hypoproteinemia and a loss of metabolic flexibility in the myocardium. The latter is characterized by a shift towards predominant glucose metabolism and glycolysis. These results demonstrate that a single exposure to severe exertional heat illness can induce long-lasting and unexpected health consequences in mammals and increased vulnerability to secondary metabolic stressors. Exposure to elevated temperatures can result in adverse health conditions; in this study, a single bout of exertional heat stroke was found to accelerate diet-induced obesity and cardiac hypertrophy, and to diminish metabolic flexibility in mouse cardiac tissue.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39820023","pmcid":"PMC11739569","openalex_id":"https://openalex.org/W4406458812","authors":[],"funders":[{"funder_name":"United States Department of Defense | United States Army | U.S. Army Corps of Engineers","grant_id":"W81XWH-19-2-0050","title":null},{"funder_name":"BK and Betty Stevens Endowment University of Florida Foundation","grant_id":"","title":null}],"total_grants":2,"fwci":2.4996,"citation_percentile":0.87614215,"influential_citations":0,"citation_trend":[{"year":2025,"count":1},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.nature.com/articles/s42003-025-07484-3.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/s42003-025-07484-3.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s42003-025-07484-3","host_type":"publisher"},{"url":"https://doi.org/10.1038/s42003-025-07484-3","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39820023","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11739569","host_type":"repository"},{"url":"https://doaj.org/article/045e494550ae4b5c82965bf066e2b1bb","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11739569/pdf/42003_2025_Article_7484.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11739569","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11739569?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Thermoregulation and physiological responses","Adipose Tissue and Metabolism","Exercise and Physiological Responses"],"mesh_terms":["Animals","Disease Models, Animal","Energy Metabolism","Physical Exertion","Male","Mice, Inbred C57BL","Myocardium","Obesity","Heat Stroke","Mice"],"keywords":["Medicine","Cardiology","Stroke (engine)","Flexibility (engineering)","Internal medicine","Obesity","Engineering","Mechanical engineering"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T01:21:30.997730Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}