{"doi":"10.1038/s42003-024-07435-4","title":"The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells","abstract":"Aedes mosquitoes transmit pathogenic arthropod-borne (arbo) viruses, putting nearly half the world's population at risk. Blocking virus replication in mosquitoes is a promising approach to prevent arbovirus transmission, the development of which requires in-depth knowledge of virus-host interactions and mosquito immunity. By integrating multi-omics data, we find that heat shock factor 1 (Hsf1) regulates eight small heat shock protein (sHsp) genes within one topologically associated domain in the genome of the Aedes aegypti mosquito. This Hsf1-sHsp cascade acts as an early response against chikungunya virus infection and shows pan-antiviral activity against chikungunya, Sindbis, and dengue virus as well as the insect-specific Agua Salud alphavirus in Ae. aegypti cells and against chikungunya virus and O'nyong-nyong virus in Aedes albopictus and Anopheles gambiae cells, respectively. Our comprehensive in vitro data suggest that Hsf1 could serve as a promising target for the development of novel intervention strategies to limit arbovirus transmission by mosquitoes.","journal":"Communications Biology","year":2025,"id":520426,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9583,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1389965,"name":"Michelle Schinkel","orcid":"0000-0002-5412-766X","position":1,"is_corresponding":false},{"id":1389966,"name":"Lisa Chiggiato","orcid":"0000-0003-2784-8880","position":2,"is_corresponding":false},{"id":1389967,"name":"Samara Rosendo Machado","orcid":"0000-0003-4312-6415","position":3,"is_corresponding":false},{"id":557642,"name":"Gijs J. Overheul","orcid":"0000-0002-8356-8165","position":4,"is_corresponding":false},{"id":262208,"name":"Pascal Miesen","orcid":"0000-0002-6378-0871","position":5,"is_corresponding":false},{"id":262213,"name":"Ronald P. van Rij","orcid":"0000-0003-0221-4689","position":6,"is_corresponding":false},{"id":1167436,"name":"Jieqiong Qu","orcid":"0000-0003-0915-1342","position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":null,"created_at":"2026-07-19T02:49:28.470782Z","pmid":"39863754","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}