{"doi":"10.1038/s42003-024-06861-8","title":"Dim light at night unmasks sex-specific differences in circadian and autonomic regulation of cardiovascular physiology","abstract":"Shift work and artificial light at night disrupt the entrainment of endogenous circadian rhythms in physiology and behavior to the day-night cycle. We hypothesized that exposure to dim light at night (dLAN) disrupts feeding rhythms, leading to sex-specific changes in autonomic signaling and day-night heart rate and blood pressure rhythms. Compared to mice housed in 12-hour light/12-hour dark cycles, mice exposed to dLAN showed reduced amplitudes in day-night feeding, heart rate, and blood pressure rhythms. In female mice, dLAN reduced the amplitude of day-night cardiovascular rhythms by decreasing the relative sympathetic regulation at night, while in male mice, it did so by increasing the relative sympathetic regulation during the daytime. Time-restricted feeding to the dim light cycle reversed these autonomic changes in both sexes. We conclude that dLAN induces sex-specific changes in autonomic regulation of heart rate and blood pressure, and time-restricted feeding may represent a chronotherapeutic strategy to mitigate the cardiovascular impact of light at night.","journal":"Communications Biology","year":2024,"id":428340,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1230000,"name":"Dema Sami","orcid":null,"position":1,"is_corresponding":false},{"id":1230001,"name":"Allison Ehlman","orcid":null,"position":2,"is_corresponding":false},{"id":1230002,"name":"Isabel Stumpf","orcid":null,"position":3,"is_corresponding":false},{"id":756675,"name":"Tanya Seward","orcid":null,"position":4,"is_corresponding":false},{"id":1229559,"name":"Wen Su","orcid":"0000-0003-1057-9469","position":5,"is_corresponding":false},{"id":851780,"name":"Ming Gong","orcid":"0000-0002-3554-7378","position":6,"is_corresponding":false},{"id":336061,"name":"Elizabeth A. Schroder","orcid":"0000-0003-0923-4420","position":7,"is_corresponding":false},{"id":336067,"name":"Brian P. Delisle","orcid":"0000-0002-2146-327X","position":8,"is_corresponding":false},{"id":1229558,"name":"Abhilash Prabhat","orcid":"0000-0001-7598-5519","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T01:58:57.592578Z","pmid":"39333678","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}