{"doi":"10.1038/s42003-024-06239-w","title":"The implications of APOBEC3-mediated C-to-U RNA editing for human disease","abstract":"Intra-organism biodiversity is thought to arise from epigenetic modification of constituent genes and post-translational modifications of translated proteins. Here, we show that post-transcriptional modifications, like RNA editing, may also contribute. RNA editing enzymes APOBEC3A and APOBEC3G catalyze the deamination of cytosine to uracil. RNAsee (RNA site editing evaluation) is a computational tool developed to predict the cytosines edited by these enzymes. We find that 4.5% of non-synonymous DNA single nucleotide polymorphisms that result in cytosine to uracil changes in RNA are probable sites for APOBEC3A/G RNA editing; the variant proteins created by such polymorphisms may also result from transient RNA editing. These polymorphisms are associated with over 20% of Medical Subject Headings across ten categories of disease, including nutritional and metabolic, neoplastic, cardiovascular, and nervous system diseases. Because RNA editing is transient and not organism-wide, future work is necessary to confirm the extent and effects of such editing in humans.","journal":"Communications Biology","year":2024,"id":438304,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":480751,"name":"Zackary Falls","orcid":"0000-0003-4116-0441","position":1,"is_corresponding":false},{"id":545623,"name":"Sapan Mandloi","orcid":"0000-0001-7486-7166","position":2,"is_corresponding":false},{"id":243145,"name":"Brahm H. Segal","orcid":"0000-0001-5043-7380","position":3,"is_corresponding":false},{"id":566442,"name":"Bora E. Baysal","orcid":"0000-0003-3382-1545","position":4,"is_corresponding":false},{"id":28980,"name":"Ram Samudrala","orcid":"0000-0001-9069-8497","position":5,"is_corresponding":false},{"id":545624,"name":"Peter L. Elkin","orcid":"0000-0001-9616-6811","position":6,"is_corresponding":false},{"id":1167569,"name":"Melissa Van Norden","orcid":"0000-0002-6190-7381","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:00:38.888629Z","pmid":"38704509","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}