{"doi":"10.1038/s42003-023-05751-9","title":"CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis","abstract":"CCDC88B is a risk factor for several chronic inflammatory diseases in humans and its inactivation causes a migratory defect in DCs in mice. CCDC88B belongs to a family of cytoskeleton-associated scaffold proteins that feature protein:protein interaction domains. Here, we identified the Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) and the RAS Protein Activator Like 3 (RASAL3) as CCDC88B physical and functional interactors. Mice defective in Arhgef2 or Rasal3 show dampened neuroinflammation, and display altered cellular response and susceptibility to colitis; ARHGEF2 maps to a human Chromosome 1 locus associated with susceptibility to IBD. Arhgef2 and Rasal3 mutant DCs show altered migration and motility in vitro, causing either reduced (Arhgef2) or enhanced (Rasal3) migratory properties. The CCDC88B/RASAL3/ARHGEF2 complex appears to regulate DCs migration by modulating activation of RHOA, with ARHGEF2 and RASAL3 acting in opposite regulatory fashions, providing a molecular mechanism for the involvement of these proteins in DCs immune functions.","journal":"Communications Biology","year":2024,"id":453940,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":558864,"name":"David Langlais","orcid":"0000-0003-4429-0110","position":1,"is_corresponding":false},{"id":1276785,"name":"Thiviya Jeyakumar","orcid":"0000-0002-4647-555X","position":2,"is_corresponding":false},{"id":1276786,"name":"Maria J. Polyak","orcid":"0000-0003-3762-9278","position":3,"is_corresponding":false},{"id":1276787,"name":"Luc Galarneau","orcid":"0000-0003-1871-9331","position":4,"is_corresponding":false},{"id":274433,"name":"Romain Cayrol","orcid":"0000-0003-2745-2704","position":5,"is_corresponding":false},{"id":463093,"name":"Hua Jiang","orcid":"0000-0002-7561-3085","position":6,"is_corresponding":false},{"id":321289,"name":"Kelly R. Molloy","orcid":"0009-0006-3142-4481","position":7,"is_corresponding":false},{"id":858854,"name":"Guoyue Xu","orcid":"0000-0002-7699-8837","position":8,"is_corresponding":false},{"id":1276788,"name":"Harumi Suzuki","orcid":"0000-0003-3616-9361","position":9,"is_corresponding":false},{"id":463098,"name":"John LaCava","orcid":"0000-0002-6307-7713","position":10,"is_corresponding":false},{"id":558872,"name":"Philippe Gros","orcid":"0000-0002-0114-1978","position":11,"is_corresponding":false},{"id":1276789,"name":"Nassima Fodil","orcid":"0000-0002-4319-5560","position":12,"is_corresponding":false},{"id":1277183,"name":"Jean-Frédéric Olivier","orcid":null,"position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T02:03:03.428151Z","pmid":"38200184","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}