{"doi":"10.1038/s42003-022-04357-x","title":"Gut microbiota modulates lung fibrosis severity following acute lung injury in mice","abstract":"Independent studies demonstrate the significance of gut microbiota on the pathogenesis of chronic lung diseases; yet little is known regarding the role of the gut microbiota in lung fibrosis progression. Here we show, using the bleomycin murine model to quantify lung fibrosis in C57BL/6 J mice housed in germ-free, animal biosafety level 1 (ABSL-1), or animal biosafety level 2 (ABSL-2) environments, that germ-free mice are protected from lung fibrosis, while ABSL-1 and ABSL-2 mice develop mild and severe lung fibrosis, respectively. Metagenomic analysis reveals no notable distinctions between ABSL-1 and ABSL-2 lung microbiota, whereas greater microbial diversity, with increased Bifidobacterium and Lactobacilli, is present in ABSL-1 compared to ABSL-2 gut microbiota. Flow cytometric analysis reveals enhanced IL-6/STAT3/IL-17A signaling in pulmonary CD4 + T cells of ABSL-2 mice. Fecal transplantation of ABSL-2 stool into germ-free mice recapitulated more severe fibrosis than transplantation of ABSL-1 stool. Lactobacilli supernatant reduces collagen 1 A production in IL-17A- and TGFβ1-stimulated human lung fibroblasts. These findings support a functional role of the gut microbiota in augmenting lung fibrosis severity.","journal":"Communications Biology","year":2022,"id":241404,"datarank":0.5676284450877392,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.0,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9524,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":829144,"name":"Elizabeth K. Mallott","orcid":"0000-0001-5446-8563","position":1,"is_corresponding":false},{"id":657642,"name":"Austin Chapman","orcid":null,"position":2,"is_corresponding":false},{"id":870320,"name":"Joseph C. Van Amburg","orcid":"0000-0002-1410-6995","position":3,"is_corresponding":false},{"id":870321,"name":"Hongmei Wu","orcid":"0000-0002-1930-1183","position":4,"is_corresponding":false},{"id":829659,"name":"Binal Shah-Gandhi","orcid":null,"position":5,"is_corresponding":false},{"id":870765,"name":"Nandita Dey","orcid":null,"position":6,"is_corresponding":false},{"id":829591,"name":"Marina E. Kirkland","orcid":"0000-0002-8389-7436","position":7,"is_corresponding":false},{"id":263090,"name":"M. Blanca Piazuelo","orcid":"0000-0002-0000-1324","position":8,"is_corresponding":false},{"id":617917,"name":"Joyce E. Johnson","orcid":"0000-0002-3680-4372","position":9,"is_corresponding":false},{"id":15360,"name":"Gordon R. Bernard","orcid":"0000-0002-4721-3068","position":10,"is_corresponding":false},{"id":740143,"name":"Sobha R. Bodduluri","orcid":"0000-0002-6736-3573","position":11,"is_corresponding":false},{"id":870322,"name":"Steven E. Davison","orcid":"0000-0003-1361-8128","position":12,"is_corresponding":false},{"id":367316,"name":"Bodduluri Haribabu","orcid":"0000-0002-8261-3294","position":13,"is_corresponding":false},{"id":250053,"name":"Seth R. Bordenstein","orcid":"0000-0001-7346-0954","position":14,"is_corresponding":false},{"id":245352,"name":"Wonder P. Drake","orcid":"0000-0001-9406-3130","position":15,"is_corresponding":false},{"id":656604,"name":"O.S. Chioma","orcid":"0000-0001-8323-490X","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:22:56.227656Z","pmid":"36543914","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}