{"doi":"10.1038/s42003-022-03596-2","title":"Activated-memory T cells influence naïve T cell fate: a noncytotoxic function of human CD8 T cells","abstract":"Abstract T cells are endowed with the capacity to sense their environment including other T cells around them. They do so to set their numbers and activation thresholds. This form of regulation has been well-studied within a given T cell population – i.e., within the naïve or memory pool; however, less is known about the cross-talk between T cell subsets. Here, we tested whether memory T cells interact with and influence surrounding naïve T cells. We report that human naïve CD8 T cells (T N ) undergo phenotypic and transcriptional changes in the presence of autologous activated-memory CD8 T cells (T Mem ). Following in vitro co-culture with activated central memory cells (T CM ), ~3% of the T N acquired activation/memory canonical markers (CD45RO and CD95) in an MHC-I dependent-fashion. Using scRNA-seq, we also observed that ~3% of the T N acquired an activated/memory signature, while ~84% developed a unique activated transcriptional profile hybrid between naïve and activated memory. Pseudotime trajectory analysis provided further evidence that T N with an activated/memory or hybrid phenotype were derived from T N . Our data reveal a non-cytotoxic function of T Mem with potential to activate autologous T N into the activated/memory pool. These findings may have implications for host-protection and autoimmunity that arises after vaccination, infection or transplantation.","journal":"Communications Biology","year":2022,"id":275413,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":945508,"name":"Mouhamad Al Moussawy","orcid":null,"position":1,"is_corresponding":false},{"id":462113,"name":"Khodor I. Abou‐Daya","orcid":"0000-0001-8788-2728","position":2,"is_corresponding":false},{"id":325784,"name":"Camila Macedo","orcid":"0000-0003-3624-1896","position":3,"is_corresponding":false},{"id":945509,"name":"Amira Hosni-Ahmed","orcid":null,"position":4,"is_corresponding":false},{"id":279404,"name":"Silvia Liu","orcid":"0000-0002-1840-9520","position":5,"is_corresponding":false},{"id":945510,"name":"Mariam Juya","orcid":null,"position":6,"is_corresponding":false},{"id":327505,"name":"Alan F. Zahorchak","orcid":null,"position":7,"is_corresponding":false},{"id":325790,"name":"Diana Metes","orcid":"0000-0002-5500-5074","position":8,"is_corresponding":false},{"id":325791,"name":"Angus W. Thomson","orcid":"0000-0001-6731-8871","position":9,"is_corresponding":false},{"id":325789,"name":"Fadi G. Lakkis","orcid":"0000-0001-9937-2637","position":10,"is_corresponding":false},{"id":271004,"name":"Hossam A. Abdelsamed","orcid":"0000-0002-5448-6056","position":11,"is_corresponding":false},{"id":782570,"name":"Kazuki Sasaki","orcid":"0009-0006-9126-0351","position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:28:21.971703Z","pmid":"35768564","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}