{"doi":"10.1038/s42003-021-01842-7","title":"Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer","abstract":"Small cell lung cancer (SCLC) is classified as a high-grade neuroendocrine (NE) tumor, but a subset of SCLC has been termed \"variant\" due to the loss of NE characteristics. In this study, we computed NE scores for patient-derived SCLC cell lines and xenografts, as well as human tumors. We aligned NE properties with transcription factor-defined molecular subtypes. Then we investigated the different immune phenotypes associated with high and low NE scores. We found repression of immune response genes as a shared feature between classic SCLC and pulmonary neuroendocrine cells of the healthy lung. With loss of NE fate, variant SCLC tumors regain cell-autonomous immune gene expression and exhibit higher tumor-immune interactions. Pan-cancer analysis revealed this NE lineage-specific immune phenotype in other cancers. Additionally, we observed MHC I re-expression in SCLC upon development of chemoresistance. These findings may help guide the design of treatment regimens in SCLC.","journal":"Communications Biology","year":2021,"id":149771,"datarank":0.6952093482344455,"base_score":4.634728988229636,"endowment":4.634728988229636,"self_citation_contribution":0.6952093482344455,"citation_network_contribution":0.0,"self_endowment_contribution":0.6952093482344455,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":102,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9596,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":636708,"name":"Hongyu Liu","orcid":"0009-0002-6718-7976","position":1,"is_corresponding":false},{"id":471352,"name":"Fang Huang","orcid":"0000-0003-1105-0874","position":2,"is_corresponding":false},{"id":69930,"name":"Junya Fujimoto","orcid":"0000-0003-4813-3163","position":3,"is_corresponding":false},{"id":253870,"name":"Luc Girard","orcid":"0000-0002-6688-5281","position":4,"is_corresponding":false},{"id":636709,"name":"Jun Chen","orcid":"0000-0002-2362-5359","position":5,"is_corresponding":false},{"id":636710,"name":"Li Y","orcid":"0000-0001-6102-2949","position":6,"is_corresponding":false},{"id":416819,"name":"Yu‐An Zhang","orcid":null,"position":7,"is_corresponding":false},{"id":636711,"name":"Dhruba Deb","orcid":"0000-0003-4828-4623","position":8,"is_corresponding":false},{"id":637540,"name":"Victor Stastny","orcid":null,"position":9,"is_corresponding":false},{"id":338880,"name":"Karine Pozo","orcid":"0000-0002-2749-9353","position":10,"is_corresponding":false},{"id":74115,"name":"Christin S. 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