{"doi":"10.1038/s42003-021-01832-9","title":"Brain pathology recapitulates physiology: A network meta-analysis","abstract":"Abstract Network architecture is a brain-organizational motif present across spatial scales from cell assemblies to distributed systems. Structural pathology in some neurodegenerative disorders selectively afflicts a subset of functional networks, motivating the network degeneration hypothesis (NDH). Recent evidence suggests that structural pathology recapitulating physiology may be a general property of neuropsychiatric disorders. To test this possibility, we compared functional and structural network meta-analyses drawing upon the BrainMap database. The functional meta-analysis included results from >7,000 experiments of subjects performing >100 task paradigms; the structural meta-analysis included >2,000 experiments of patients with >40 brain disorders. Structure-function network concordance was high: 68% of networks matched (pFWE < 0.01), confirming the broader scope of NDH. This correspondence persisted across higher model orders. A positive linear association between disease and behavioral entropy (p = 0.0006;R 2 = 0.53) suggests nodal stress as a common mechanism. Corroborating this interpretation with independent data, we show that metabolic ‘cost’ significantly differs along this transdiagnostic/multimodal gradient.","journal":"Communications Biology","year":2021,"id":163803,"datarank":0.5570358100056463,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":0.0,"self_endowment_contribution":0.5570358100056463,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":323224,"name":"Peter T. Fox","orcid":"0000-0002-0465-2028","position":1,"is_corresponding":false},{"id":683895,"name":"P. Mickle Fox","orcid":"0000-0002-4997-0003","position":2,"is_corresponding":false},{"id":683896,"name":"Franco Cauda","orcid":"0000-0003-1526-8475","position":3,"is_corresponding":false},{"id":683897,"name":"Tommaso Costa","orcid":"0000-0002-0822-862X","position":4,"is_corresponding":false},{"id":12959,"name":"Stephen M. Smith","orcid":"0000-0001-8166-069X","position":5,"is_corresponding":false},{"id":106615,"name":"Simon B. Eickhoff","orcid":"0000-0001-6363-2759","position":6,"is_corresponding":false},{"id":604214,"name":"Jack L. Lancaster","orcid":null,"position":7,"is_corresponding":false},{"id":683894,"name":"Thomas J. Vanasse","orcid":"0000-0003-4672-0049","position":0,"is_corresponding":true}],"reference_count":72,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:45:22.477398Z","pmid":"33686216","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}