{"doi":"10.1038/s41598-025-85624-9","title":"Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans","abstract":"Phosphatidylcholine is a ubiquitous phospholipid. It contains a phosphocholine (PC) headgroup and polyunsaturated fatty acids that, when oxidized, form reactive oxidized phospholipids (PC-OxPLs). PC-OxPLs are pathogenic in multiple diseases and neutralized by anti-PC IgM antibodies. The levels of anti-PC IgM increase as the levels of PC-OxPLs increase and, in humans, are inversely correlated with the incidence of cardiovascular diseases and steatohepatitis. PC-OxPLs also decrease bone mass in mice. Overexpression of anti-PC IgM ameliorates atherosclerosis and steatohepatitis, increases bone mass in young mice, and protects against high fat diet- and age-associated osteoporosis. We investigated the relationship between anti-PC IgM plasma levels and bone mineral density (BMD) in a cross-sectional study of 247 participants [mean age: 65.5 (± 8.6) years] without medical conditions known to influence BMD or antibody production. Anti-PC IgM levels negatively correlated with both T- and Z-scores at the lumbar spine, femur and, to a lesser extent, the forearm. These correlations were maintained after adjustment for age, race, and sex. These results raise the possibility that higher levels of anti-PC IgM in patients with lower BMD reflect exposure to higher levels of PC-OxPLs, which are known to affect bone mass, and could be a novel risk marker for osteoporosis.","journal":"Scientific Reports","year":2025,"id":542789,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9613,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":691326,"name":"Spyridoula Maraka","orcid":"0000-0001-7259-132X","position":1,"is_corresponding":false},{"id":585527,"name":"Horace J. Spencer","orcid":"0000-0001-8176-881X","position":2,"is_corresponding":false},{"id":275482,"name":"Jeff D. Thostenson","orcid":"0009-0003-9635-5729","position":3,"is_corresponding":false},{"id":1432617,"name":"Katherine Dishongh","orcid":null,"position":4,"is_corresponding":false},{"id":1432618,"name":"Micheal Knox","orcid":null,"position":5,"is_corresponding":false},{"id":1432619,"name":"Betty Ussery","orcid":null,"position":6,"is_corresponding":false},{"id":1432620,"name":"Jesse Byrd","orcid":null,"position":7,"is_corresponding":false},{"id":1432621,"name":"Jacqueline K. Kuipers","orcid":null,"position":8,"is_corresponding":false},{"id":1432622,"name":"Sanaz Abedzadeh-Anaraki","orcid":null,"position":9,"is_corresponding":false},{"id":1432290,"name":"Chitharanjan Duvoor","orcid":"0000-0002-4349-152X","position":10,"is_corresponding":false},{"id":894987,"name":"Yuanjie Mao","orcid":"0000-0002-4196-7133","position":11,"is_corresponding":false},{"id":1042695,"name":"Lakshmi Menon","orcid":"0000-0002-4858-6771","position":12,"is_corresponding":false},{"id":482118,"name":"James S. Williams","orcid":null,"position":13,"is_corresponding":false},{"id":147828,"name":"Stavros C. Manolagas","orcid":null,"position":14,"is_corresponding":false},{"id":147825,"name":"Robert L. Jilka","orcid":null,"position":15,"is_corresponding":false},{"id":378859,"name":"Elena Ambrogini","orcid":"0000-0002-5704-6072","position":16,"is_corresponding":false},{"id":277563,"name":"Michela Palmieri","orcid":"0000-0001-9373-1133","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-19T02:53:00.171379Z","pmid":"39814831","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}