{"doi":"10.1038/s41598-024-82901-x","title":"Portable UV-C device to treat high flow of infectious aerosols generated during clinical respiratory care","abstract":"Respiratory interventions including noninvasive ventilation, continuous positive airway pressure and high-flow nasal oxygen generated infectious aerosols may increase risk of airborne disease (SARS-CoV-2, influenza virus) transmission to healthcare workers. We developed and tested a prototype portable UV-C 254 device to sterilize high flows of viral-contaminated air from a simulated patient source at airflow rates of up to 100 l/m. Our device consisted of a central quartz tube surrounded 6 high-output UV-C 254 lamps, within a larger cylinder allowing recirculation past the UV-C 254 lamps a second time before exiting the device. Testing was with nebulized A/PR/8/34 (H1N1) influenza virus. RNA extraction and qRT-PCR showed virus transited through the prototype. Turning on varying numbers of lamps controlled the dose of UVC. Viability experiments at low, medium and high (100 l/min) flows of contaminated gas were conducted with 6, 4, 2 and 1 lamp activated (single-pass and recirculation were tested). Our data show 5-log reduction in plaque forming units from a single lamp (single- pass and recirculated conditions) at high and low flows. UVC dose at 100 l/m was calculated at 11.6 mJ/cm 2 single pass and 104 mJ/cm 2 recirculated. The protype device shows high efficacy in killing nebulized influenza virus in a high flow of contaminated air.","journal":"Scientific Reports","year":2024,"id":452123,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9574,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":385867,"name":"David M. Rapoport","orcid":"0000-0002-4855-2600","position":1,"is_corresponding":false},{"id":329637,"name":"Priti Balchandani","orcid":"0000-0001-7709-5835","position":2,"is_corresponding":false},{"id":1059754,"name":"Joseph A. Borrello","orcid":"0000-0002-2319-4536","position":3,"is_corresponding":false},{"id":107923,"name":"Michael Schotsaert","orcid":"0000-0003-3156-3132","position":4,"is_corresponding":false},{"id":555489,"name":"R. F. Karlicek","orcid":"0000-0003-2688-9760","position":5,"is_corresponding":false},{"id":902109,"name":"Gabriel Laghlali","orcid":"0009-0009-7928-984X","position":6,"is_corresponding":false},{"id":803942,"name":"Prajakta Warang","orcid":"0000-0002-5571-8277","position":7,"is_corresponding":false},{"id":1057244,"name":"Seok‐Chan Park","orcid":"0000-0003-2489-2202","position":8,"is_corresponding":false},{"id":262427,"name":"Gagandeep Singh","orcid":"0000-0001-6661-3553","position":9,"is_corresponding":false},{"id":1274417,"name":"Isabella Morgan","orcid":null,"position":10,"is_corresponding":false},{"id":1274418,"name":"James Paredes","orcid":null,"position":11,"is_corresponding":false},{"id":107922,"name":"Raveen Rathnasinghe","orcid":"0000-0002-1260-2493","position":12,"is_corresponding":false},{"id":1273968,"name":"Jacob Wolf","orcid":"0000-0002-5116-4043","position":13,"is_corresponding":false},{"id":1489,"name":"Adolfo Garcı́a-Sastre","orcid":"0000-0002-6551-1827","position":14,"is_corresponding":false},{"id":555494,"name":"Richard L. Vincent","orcid":"0000-0003-3453-4070","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:02:50.407779Z","pmid":"39738586","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}