{"doi":"10.1038/s41598-024-79092-w","title":"Metabolic flexibility to lipid during exercise is not associated with metabolic health outcomes in individuals without obesity","abstract":"A low metabolic flexibility to lipid (MetF-lip) in skeletal muscle may promote ectopic lipid accumulation, thus inducing metabolic disturbances. We aimed to determine the association between MetF-lip in skeletal muscle and metabolic health outcomes in individuals without obesity. We also explored the association between MetF-lip and the inflammatory signaling pathway in skeletal muscle. This was a cross-sectional study in 17 individuals aged (median [IQR]) 55.4 [48.6, 58.5] years, with a BMI of 24.4 [22.6, 26.0] kg/m 2 . MetF-lip was assessed as the increase in relative lipid oxidation during a single exercise session (~ 50% VO 2 max, 2 hours), quantified as the drop in whole-body respiratory exchange ratio (ΔRER = RER at 2 hours - maximum RER attained). HOMA-IR, metabolic syndrome z-score, fat percentage, trunk-to-appendicular fat, and VO 2 max were included as metabolic health outcomes. The abundance of proteins of the inflammatory pathway was analyzed in resting muscle. Acute exercise progressively increased relative lipid oxidation (ΔRER = -0.04 [-0.08, -0.02]). MetF-lip was not associated with any metabolic health outcome but correlated inversely with p-p38 Thr180/Tyr182 in muscle. A low MetF-lip in skeletal muscle does not seem a major determinant of metabolic disturbances but associates with a partial activation of the inflammatory signaling in individuals without obesity.","journal":"Scientific Reports","year":2024,"id":449587,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9629,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1269861,"name":"Juan Gutiérrez‐Pino","orcid":null,"position":1,"is_corresponding":false},{"id":1269862,"name":"Thomas Hayes‐Ortiz","orcid":null,"position":2,"is_corresponding":false},{"id":413821,"name":"Hermann Zbinden‐Foncea","orcid":"0000-0002-9643-1037","position":3,"is_corresponding":false},{"id":1108377,"name":"Claudio Cabello‐Verrugio","orcid":"0000-0001-7273-2102","position":4,"is_corresponding":false},{"id":1269375,"name":"Mayalen Valero‐Breton","orcid":"0000-0001-6552-2262","position":5,"is_corresponding":false},{"id":1205418,"name":"Mauro Tuñón‐Suárez","orcid":"0000-0002-3085-9057","position":6,"is_corresponding":false},{"id":1269376,"name":"Ronald Vargas-Foitzick","orcid":"0000-0003-4466-1276","position":7,"is_corresponding":false},{"id":1129347,"name":"José E. Galgani","orcid":"0000-0001-9793-8561","position":8,"is_corresponding":false},{"id":1046165,"name":"Rodrigo Fernández‐Verdejo","orcid":"0000-0002-5948-2281","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T02:02:20.585759Z","pmid":"39562632","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}