{"doi":"10.1038/s41598-024-78308-3","title":"The interplay of age, gender and amyloid on brain and cognition in mid-life and older adults","abstract":"Deficits in memory are seen as a canonical sign of aging and a prodrome to dementia in older adults. However, our understanding of age-related cognition and brain morphology occurring throughout a broader spectrum of adulthood remains limited. We quantified the relationship between cognitive function and brain morphology (sulcal width, SW) using three cross-sectional observational datasets (PISA, AIBL, ADNI) from mid-life to older adulthood, assessing the influence of age, sex, amyloid (Aβ) and genetic risk for dementia. The data comprised cognitive, genetic and neuroimaging measures of a total of 1570 non-clinical mid-life and older adults (mean age 72, range 49-90 years, 1330 males) and 1365 age- and sex-matched adults with mild cognitive impairment (MCI) or Alzheimer's disease (AD). Among non-clinical adults, we found robust modes of co-variation between regional SW and multidomain cognitive function that differed between the mid-life and older age range. These cortical and cognitive profiles derived from healthy cohorts predicted out-of-sample AD and MCI. Furthermore, Aβ-deposition and educational attainment levels were associated with cognition but not SW. These findings underscoring the complex interplay between factors influencing cognition and brain structure from mid-life onwards, providing valuable insights for future research into neurodegeneration and the development of future screening algorithms.","journal":"Scientific Reports","year":2024,"id":466716,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8135,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1298848,"name":"Renate Thienel","orcid":"0000-0003-0381-7828","position":1,"is_corresponding":false},{"id":329492,"name":"Michelle K. Lupton","orcid":"0000-0002-7274-7299","position":2,"is_corresponding":false},{"id":329512,"name":"Christine C. Guo","orcid":"0000-0003-1530-0172","position":3,"is_corresponding":false},{"id":329507,"name":"Philip Mosley","orcid":"0000-0003-1721-3419","position":4,"is_corresponding":false},{"id":1298849,"name":"Anna Behler","orcid":"0000-0001-7129-7006","position":5,"is_corresponding":false},{"id":294689,"name":"Joseph Giorgio","orcid":"0000-0003-3704-5977","position":6,"is_corresponding":false},{"id":329494,"name":"Robert Adam","orcid":"0000-0003-0053-7919","position":7,"is_corresponding":false},{"id":329502,"name":"Amelia Ceslis","orcid":"0000-0002-5343-0018","position":8,"is_corresponding":false},{"id":236163,"name":"Pierrick Bourgeat","orcid":"0000-0002-2605-4766","position":9,"is_corresponding":false},{"id":329500,"name":"Amir Fazlollahi","orcid":"0000-0001-5886-0511","position":10,"is_corresponding":false},{"id":230036,"name":"Paul Maruff","orcid":"0000-0002-6947-9537","position":11,"is_corresponding":false},{"id":55007,"name":"Christopher C. Rowe","orcid":"0000-0003-3910-2453","position":12,"is_corresponding":false},{"id":230035,"name":"Colin L. Masters","orcid":"0000-0003-3072-7940","position":13,"is_corresponding":false},{"id":230039,"name":"Jürgen Fripp","orcid":"0000-0001-9705-0079","position":14,"is_corresponding":false},{"id":329493,"name":"Gail Robinson","orcid":"0000-0002-0078-0364","position":15,"is_corresponding":false},{"id":329513,"name":"Michael Breakspear","orcid":"0000-0003-4943-3969","position":16,"is_corresponding":false},{"id":329509,"name":"Léonie Borne","orcid":"0000-0002-1577-0257","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:05:06.743102Z","pmid":"39516511","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}