{"doi":"10.1038/s41598-024-77151-w","title":"Qualitative and quantitative analysis of 18F-GP1 positron emission tomography in thrombotic cardiovascular disease","abstract":"Abstract 18 F-GP1 is a novel highly specific radiotracer that binds to activated platelets and thrombus. We aimed to establish the observer repeatability of coronary, carotid and cerebral 18 F-GP1 uptake in patients presenting with acute myocardial infarction or ischaemic stroke. Forty-three patients presenting with acute myocardial infarction or ischaemic stroke underwent hybrid positron emission tomography (PET) and computed tomography (CT) angiography. Qualitative and quantitative assessment of 18 F-GP1 uptake was performed on coronary arteries, carotid arteries and brain parenchyma. Qualitative uptake of 18 F-GP1 had excellent intraobserver and interobserver agreement, with complete agreement for the presence or absence of visual 18 F-GP1 uptake. For quantitative analysis, there were excellent intraclass correlation coefficients for intraobserver repeatability for coronary artery, carotid artery and brain parenchymal SUV max and TBR max measurements (all ≥ 0.92). Coronary artery and brain parenchymal analyses showed the strongest agreement in SUV max values with mean biases of − 0.04 (limits of agreement − 0.21 to 0.20) and 0.02 (limits of agreement − 0.29 to 0.32) respectively. There was good interclass correlation coefficients for interobserver repeatability for coronary artery, carotid artery and brain parenchymal SUV max and TBR max measurements (all ≥ 0.89). The strongest interobserver agreement was seen with brain parenchymal SUV max (mean SUV max 1.95 ± 0.94) and TBR max (mean TBR max 9.55 ± 6.56) with mean biases of − 0.05 (limits of agreement − 0.37 to 0.27) and 0.04 (limits of agreement − 0.59 to 0.52) respectively. Visual qualitative and quantitative 18 F-GP1 PET-CT image analyses provide robust and repeatable measurements of activated platelets and thrombi within the coronary arteries, carotid arteries and brain parenchyma.","journal":"Scientific Reports","year":2024,"id":505753,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9487,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":259166,"name":"Evangelos Tzolos","orcid":"0000-0003-0038-043X","position":1,"is_corresponding":false},{"id":1356549,"name":"Shruti Joshi","orcid":"0000-0001-9874-6211","position":2,"is_corresponding":false},{"id":356995,"name":"Rong Bing","orcid":"0000-0002-8305-4906","position":3,"is_corresponding":false},{"id":247000,"name":"Jack Andrews","orcid":"0000-0003-4593-9655","position":4,"is_corresponding":false},{"id":1356550,"name":"Krithika Loganath","orcid":"0000-0003-1378-306X","position":5,"is_corresponding":false},{"id":1217461,"name":"Neil Craig","orcid":"0000-0002-7370-5541","position":6,"is_corresponding":false},{"id":1217459,"name":"Craig Balmforth","orcid":"0009-0005-1991-0017","position":7,"is_corresponding":false},{"id":1356551,"name":"Laura Clark","orcid":"0000-0003-4765-0409","position":8,"is_corresponding":false},{"id":511490,"name":"Christophe Lucatelli","orcid":"0000-0001-9866-7257","position":9,"is_corresponding":false},{"id":877586,"name":"Mark G. MacAskill","orcid":"0000-0001-5355-3109","position":10,"is_corresponding":false},{"id":246987,"name":"Adriana Tavares","orcid":"0000-0001-7505-9144","position":11,"is_corresponding":false},{"id":877587,"name":"Tim Clark","orcid":"0000-0001-6925-3979","position":12,"is_corresponding":false},{"id":655688,"name":"Nicholas L. Mills","orcid":"0000-0003-0533-7991","position":13,"is_corresponding":false},{"id":877589,"name":"Jennifer Nash","orcid":"0000-0001-7523-1127","position":14,"is_corresponding":false},{"id":259171,"name":"Damini Dey","orcid":"0000-0003-2236-6970","position":15,"is_corresponding":false},{"id":259173,"name":"Piotr J. Slomka","orcid":"0000-0002-6110-938X","position":16,"is_corresponding":false},{"id":840256,"name":"Norman Koglin","orcid":"0000-0001-7583-8201","position":17,"is_corresponding":false},{"id":597269,"name":"Andrew Stephens","orcid":"0000-0001-5052-6586","position":18,"is_corresponding":false},{"id":246999,"name":"Marc R. Dweck","orcid":"0000-0001-9847-5917","position":19,"is_corresponding":false},{"id":235799,"name":"Michelle C. Williams","orcid":"0000-0003-3556-2428","position":20,"is_corresponding":false},{"id":96434,"name":"William Whiteley","orcid":"0000-0002-4816-8991","position":21,"is_corresponding":false},{"id":247002,"name":"Edwin J.R. van Beek","orcid":"0000-0002-2777-5071","position":22,"is_corresponding":false},{"id":17637,"name":"Joanna M. Wardlaw","orcid":"0000-0002-9812-6642","position":23,"is_corresponding":false},{"id":259172,"name":"David E. Newby","orcid":"0000-0001-7971-4628","position":24,"is_corresponding":false},{"id":1356548,"name":"Beth Whittington","orcid":"0000-0003-2833-5980","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-19T02:10:47.170978Z","pmid":"39500930","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}