{"doi":"10.1038/s41598-024-73274-2","title":"Pan-cancer analysis of the immunological and oncogenic roles of ATAD2 with verification in papillary thyroid carcinoma","abstract":null,"journal":"Scientific Reports","year":2024,"id":628875,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":590237,"name":"Yaxin Zhao","orcid":null,"position":1,"is_corresponding":false},{"id":1334807,"name":"Peng Huang","orcid":"0000-0003-3011-3359","position":2,"is_corresponding":false},{"id":1572996,"name":"Zhaoyi Wu","orcid":"0000-0001-9465-1485","position":3,"is_corresponding":false},{"id":1628447,"name":"Dengjie Ouyang","orcid":null,"position":4,"is_corresponding":false},{"id":1628448,"name":"Adolphus Osei Nyarko","orcid":null,"position":5,"is_corresponding":false},{"id":268822,"name":"Lei Ai","orcid":"0000-0002-2802-5774","position":6,"is_corresponding":false},{"id":1628449,"name":"Zhejia Zhang","orcid":null,"position":7,"is_corresponding":false},{"id":983506,"name":"Shi Chang","orcid":"0000-0001-5291-0151","position":8,"is_corresponding":false},{"id":1628446,"name":"Zhecheng Li","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Pan-cancer analysis of the immunological and oncogenic roles of ATAD2 with verification in papillary thyroid carcinoma","abstract":"ATAD2 (ATPase Family AAA Domain-Containing 2) is highly expressed across varies tumor types, yet its common roles in tumor progression and immune interaction remain unclear. We analyzed the expression and alteration profiles of ATAD2, along with its diagnostic and prognostic role in pan-cancer, utilizing TCGA, GTEx, CPTAC, HPA, and cBioPortal databases. Furthermore, we examined the relationship between ATAD2 and immune infiltration utilizing single-cell sequencing data and TCGA database. Additionally, the expression and oncogenic functions of ATAD2 were verified in papillary thyroid carcinoma (PTC) through MTT, wound-healing, transwell, and flow cytometry assays. Our results revealed significant overexpression of ATAD2 in most cancers, strongly associated with poor prognosis. Amplification was the most frequent alteration type of ATAD2, with its mutation correlating with improved overall survival. ATAD2 was positively correlated with multiple inhibitory immune checkpoints and closely associated with the immunosuppressive microenvironment, particularly in PTC. In vitro experiments demonstrated that ATAD2 promoted the proliferation, migration, and invasion of PTC cells by activating the PI3K-AKT pathway and modulating the G1/S cell cycle checkpoint. Collectively, ATAD2 holds promise as a biomarker for pan-cancer diagnosis and prognosis, as well as a predictor of immunotherapeutic responsiveness and a therapeutic target to enhance the efficacy of existing anti-tumor immune therapies.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39333272","pmcid":"PMC11436736","openalex_id":"https://openalex.org/W4402921522","authors":[],"funders":[{"funder_name":"The Research and Innovation Project Foundation for Graduate in Hunan Province","grant_id":"CX20230377","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81974423","title":null}],"total_grants":2,"fwci":0.9857,"citation_percentile":0.74371151,"influential_citations":0,"citation_trend":[{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1038/s41598-024-73274-2","host_type":"journal"},{"url":"https://doi.org/10.1038/s41598-024-73274-2","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41598-024-73274-2.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41598-024-73274-2","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39333272","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11436736","host_type":"repository"},{"url":"https://doaj.org/article/8d4d1a984c09419c807ec656469e6b26","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11436736","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11436736?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Protein Degradation and Inhibitors","Ubiquitin and proteasome pathways","Cancer-related gene regulation","Humans","Thyroid Cancer, Papillary","ATPases Associated with Diverse Cellular Activities","Thyroid Neoplasms","DNA-Binding Proteins","Prognosis","Cell Proliferation","Cell Line, Tumor","Tumor Microenvironment","Gene Expression Regulation, Neoplastic","Cell Movement","Biomarkers, Tumor","Mutation","Male","Female"],"mesh_terms":["ATPases Associated with Diverse Cellular Activities","Thyroid Cancer, Papillary","Cell Movement","DNA-Binding Proteins","Female","Humans","Male","Mutation","Prognosis","Thyroid Neoplasms","Biomarkers, Tumor","Gene Expression Regulation, Neoplastic","Cell Line, Tumor","Cell Proliferation","Tumor Microenvironment"],"keywords":["Cancer","Thyroid carcinoma","Papillary carcinoma","Carcinoma","Thyroid cancer","Cancer research","Medicine","Thyroid","Biology","Oncology","Pathology","Internal medicine","therapeutic target","Papillary Thyroid Carcinoma","Tumor Immune Microenvironment","Pan-cancer","Atad2"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T15:27:03.758887Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}