{"doi":"10.1038/s41598-024-68605-2","title":"HIV co-infection increases the risk of post-tuberculosis mortality among persons who initiated treatment for drug-resistant tuberculosis","abstract":"Little is known regarding the relationship between common comorbidities in persons with tuberculosis (TB) (including human immunodeficiency virus [HIV], diabetes, and hepatitis C virus [HCV]) and post-TB mortality. We conducted a retrospective cohort study among persons who initiated treatment for rifampicin-resistant or multi/extensively drug-resistant (RR or M/XDR) TB reported to the country of Georgia's TB surveillance during 2009-2017. Exposures included HIV serologic status, diabetes, and HCV status. Our outcome was all-cause post-TB mortality determined by cross-validating vital status with Georgia's death registry through November 2019. We estimated adjusted hazard rate ratios (aHR) and 95% confidence intervals (CI) of post-TB mortality among participants with and without comorbidities using cause-specific hazard regressions. Among 1032 eligible participants, 34 (3.3%) died during treatment and 87 (8.7%) died post-TB treatment. The median time to post-TB death was 21 months (interquartile range 7-39) after TB treatment. After adjusting for confounders, the hazard rates of post-TB mortality were higher among participants with HIV co-infection (aHR = 3.74, 95%CI 1.77-7.91) compared to those without HIV co-infection. In our cohort, post-TB mortality occurred most commonly in the first 3 years post-TB treatment. Linkage to care for common TB comorbidities post-treatment may reduce post-TB mortality rates.","journal":"Scientific Reports","year":2024,"id":437333,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9627,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":338061,"name":"Maia Kipiani","orcid":null,"position":1,"is_corresponding":false},{"id":385104,"name":"Nino Lomtadze","orcid":"0009-0000-8064-1956","position":2,"is_corresponding":false},{"id":385102,"name":"Nestani Tukvadze","orcid":"0000-0002-0276-1204","position":3,"is_corresponding":false},{"id":385103,"name":"Zaza Avaliani","orcid":"0000-0002-8790-3282","position":4,"is_corresponding":false},{"id":311217,"name":"Henry M. Blumberg","orcid":"0000-0002-3110-2443","position":5,"is_corresponding":false},{"id":727356,"name":"Katherine E. Masyn","orcid":"0000-0001-5337-1137","position":6,"is_corresponding":false},{"id":1172296,"name":"Richard B. Rothenberg","orcid":null,"position":7,"is_corresponding":false},{"id":332451,"name":"Russell R. Kempker","orcid":"0000-0002-7188-4996","position":8,"is_corresponding":false},{"id":231932,"name":"Matthew J. Magee","orcid":"0000-0002-8068-5796","position":9,"is_corresponding":false},{"id":385101,"name":"Argita D. Salindri","orcid":"0000-0003-0962-0348","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T02:00:29.872940Z","pmid":"39394335","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}