{"doi":"10.1038/s41598-024-68447-y","title":"Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area","abstract":"Low muscle mass is associated with numerous adverse outcomes independent of other associated comorbid diseases. We aimed to predict and understand an individual's risk for developing low muscle mass using proteomics and machine learning. We identified eight biomarkers associated with low pectoralis muscle area (PMA). We built three random forest classification models that used either clinical measures, feature selected biomarkers, or both to predict development of low PMA. The area under the receiver operating characteristic curve for each model was: clinical-only = 0.646, biomarker-only = 0.740, and combined = 0.744. We displayed the heterogenetic nature of an individual's risk for developing low PMA and identified two distinct subtypes of participants who developed low PMA. While additional validation is required, our methods for identifying and understanding individual and group risk for low muscle mass could be used to enable developments in the personalized prevention of low muscle mass.","journal":"Scientific Reports","year":2024,"id":480929,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9673,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":834241,"name":"J.W. Chiles","orcid":"0000-0002-9935-6319","position":1,"is_corresponding":false},{"id":385668,"name":"Stefanie Mason","orcid":"0000-0002-7649-9026","position":2,"is_corresponding":false},{"id":1320327,"name":"Toru Shirahata","orcid":"0000-0002-8975-6618","position":3,"is_corresponding":false},{"id":274491,"name":"Víctor M. Castro","orcid":"0000-0001-7390-6354","position":4,"is_corresponding":false},{"id":24860,"name":"Elizabeth Regan","orcid":null,"position":5,"is_corresponding":false},{"id":419515,"name":"Bina Choi","orcid":"0000-0003-1472-9639","position":6,"is_corresponding":false},{"id":677224,"name":"Nancy Yuan","orcid":"0000-0002-8325-8255","position":7,"is_corresponding":false},{"id":285683,"name":"Alejandro A. Díaz","orcid":"0000-0001-5037-2919","position":8,"is_corresponding":false},{"id":106131,"name":"George R. Washko","orcid":"0000-0002-2712-0569","position":9,"is_corresponding":false},{"id":24993,"name":"Merry‐Lynn McDonald","orcid":"0000-0002-2647-9422","position":10,"is_corresponding":false},{"id":267137,"name":"Raúl San Jośe Estépar","orcid":"0000-0002-3677-1996","position":11,"is_corresponding":false},{"id":385665,"name":"Samuel Y. Ash","orcid":"0000-0003-0224-6939","position":12,"is_corresponding":false},{"id":326871,"name":"Nicola A. Hanania","orcid":"0000-0003-3087-9530","position":13,"is_corresponding":false},{"id":717279,"name":"Mustafa Atik","orcid":null,"position":14,"is_corresponding":false},{"id":290522,"name":"Laura Bertrand","orcid":null,"position":15,"is_corresponding":false},{"id":716458,"name":"Aladin M. Boriek","orcid":"0000-0002-1467-5629","position":16,"is_corresponding":false},{"id":1320717,"name":"Thomas J. Monaco","orcid":null,"position":17,"is_corresponding":false},{"id":1320328,"name":"Dharani Kumari Narendra","orcid":"0000-0001-7866-7161","position":18,"is_corresponding":false},{"id":232045,"name":"Francesca Polverino","orcid":"0000-0001-9686-5698","position":19,"is_corresponding":false},{"id":1320718,"name":"Veronica V. Lenge de Rosen","orcid":null,"position":20,"is_corresponding":false},{"id":1320719,"name":"Philip W. Salas","orcid":null,"position":21,"is_corresponding":false},{"id":690788,"name":"Tianshi David Wu","orcid":"0000-0003-4906-3232","position":22,"is_corresponding":false},{"id":24957,"name":"Dawn L. DeMeo","orcid":"0000-0001-9653-0636","position":23,"is_corresponding":false},{"id":24971,"name":"Craig P. Hersh","orcid":"0000-0002-1342-4334","position":24,"is_corresponding":false},{"id":1320720,"name":"Staci M. Gagne","orcid":null,"position":26,"is_corresponding":false},{"id":422568,"name":"Francine L. Jacobson","orcid":"0000-0002-0716-2198","position":27,"is_corresponding":false},{"id":1320721,"name":"Kathryn Marentette","orcid":null,"position":28,"is_corresponding":false},{"id":1320329,"name":"Seth Wilson","orcid":"0000-0002-3157-298X","position":30,"is_corresponding":false},{"id":574728,"name":"Jeong H. Yun","orcid":"0000-0002-4361-8295","position":31,"is_corresponding":false},{"id":24685,"name":"R. Graham Barr","orcid":"0000-0001-8021-0072","position":32,"is_corresponding":false},{"id":520207,"name":"John H. M. Austin","orcid":null,"position":33,"is_corresponding":false},{"id":1320722,"name":"Maria Lorena Gomez Blum","orcid":null,"position":34,"is_corresponding":false},{"id":622645,"name":"Belinda D’Souza","orcid":null,"position":35,"is_corresponding":false},{"id":1320723,"name":"Emilay Florez","orcid":null,"position":36,"is_corresponding":false},{"id":1320724,"name":"Valeria Lopez","orcid":null,"position":37,"is_corresponding":false},{"id":1320725,"name":"Wanda Pecheco","orcid":null,"position":38,"is_corresponding":false},{"id":355005,"name":"Byron Thomashow","orcid":null,"position":39,"is_corresponding":false},{"id":382669,"name":"Chris H. Wendt","orcid":"0000-0002-0924-8745","position":40,"is_corresponding":false},{"id":382668,"name":"Arianne K. Baldomero","orcid":"0000-0002-8309-0747","position":41,"is_corresponding":false},{"id":1320726,"name":"Miranda Hassler","orcid":null,"position":42,"is_corresponding":false},{"id":382671,"name":"Ken M. Kunisaki","orcid":"0000-0001-8644-2827","position":43,"is_corresponding":false},{"id":422042,"name":"David MacDonald","orcid":"0000-0002-6718-9296","position":44,"is_corresponding":false},{"id":526913,"name":"Charlene McEvoy","orcid":"0000-0002-2813-9106","position":45,"is_corresponding":false},{"id":1320727,"name":"Nell Adams","orcid":null,"position":46,"is_corresponding":false},{"id":1320728,"name":"B.A. Heinz","orcid":null,"position":47,"is_corresponding":false},{"id":1320729,"name":"Jonathan Phelan","orcid":null,"position":48,"is_corresponding":false},{"id":1320730,"name":"Cheryl Sasse","orcid":null,"position":49,"is_corresponding":false},{"id":1194995,"name":"Eric L. Flenaugh","orcid":null,"position":50,"is_corresponding":false},{"id":1320731,"name":"Judith Delancy","orcid":null,"position":51,"is_corresponding":false},{"id":608902,"name":"Marilyn G. Foreman","orcid":"0000-0002-9405-7475","position":52,"is_corresponding":false},{"id":743480,"name":"Hirut Gebrekristos","orcid":"0000-0001-9065-9957","position":53,"is_corresponding":false},{"id":1320732,"name":"Willi Howell","orcid":null,"position":54,"is_corresponding":false},{"id":1320733,"name":"Dominique Lawson","orcid":null,"position":55,"is_corresponding":false},{"id":1320330,"name":"Mario Castro","orcid":"0000-0003-3288-6144","position":56,"is_corresponding":false},{"id":1041050,"name":"Gloria Westney","orcid":null,"position":57,"is_corresponding":false},{"id":24947,"name":"Russell P. Bowler","orcid":"0000-0003-4651-363X","position":58,"is_corresponding":false},{"id":1320734,"name":"Sophia Addi","orcid":null,"position":59,"is_corresponding":false},{"id":1320331,"name":"Elena Engel","orcid":"0000-0002-2788-2408","position":60,"is_corresponding":false},{"id":1320735,"name":"Jay Finigan","orcid":null,"position":61,"is_corresponding":false},{"id":1121912,"name":"Claire Guo","orcid":null,"position":62,"is_corresponding":false},{"id":409150,"name":"Seth Kligerman","orcid":"0000-0002-7661-408X","position":63,"is_corresponding":false},{"id":33102,"name":"David A. Lynch","orcid":"0000-0002-6329-2325","position":64,"is_corresponding":false},{"id":1320736,"name":"L. Ruvuna","orcid":null,"position":66,"is_corresponding":false},{"id":527740,"name":"Richard Rosiello","orcid":null,"position":67,"is_corresponding":false},{"id":1320332,"name":"Jean Champagne","orcid":"0000-0001-9861-9351","position":68,"is_corresponding":false},{"id":1320737,"name":"Mary Charpentier","orcid":null,"position":69,"is_corresponding":false},{"id":1320738,"name":"Theodore Girard","orcid":null,"position":70,"is_corresponding":false},{"id":1320739,"name":"Jon Jaksha","orcid":null,"position":71,"is_corresponding":false},{"id":1320740,"name":"D. N. KIRK","orcid":null,"position":72,"is_corresponding":false},{"id":1320741,"name":"Laurie Kuck","orcid":null,"position":73,"is_corresponding":false},{"id":1320742,"name":"Mohammed Quraishi","orcid":null,"position":74,"is_corresponding":false},{"id":1320743,"name":"Lucia Sears","orcid":null,"position":75,"is_corresponding":false},{"id":250084,"name":"Gerard J. Criner","orcid":"0000-0003-1267-3483","position":76,"is_corresponding":false},{"id":1320744,"name":"Elise Cortese","orcid":null,"position":77,"is_corresponding":false},{"id":526927,"name":"Chandra Dass","orcid":"0000-0002-5468-7501","position":78,"is_corresponding":false},{"id":1320745,"name":"Laurie Jameson","orcid":null,"position":79,"is_corresponding":false},{"id":791753,"name":"Nathaniel Marchetti","orcid":"0000-0003-3229-8879","position":80,"is_corresponding":false},{"id":1320746,"name":"Francine McGonagle","orcid":null,"position":81,"is_corresponding":false},{"id":1320747,"name":"Lauren Miller","orcid":null,"position":82,"is_corresponding":false},{"id":1320748,"name":"Kim Selwood","orcid":null,"position":83,"is_corresponding":false},{"id":1116058,"name":"Kartik Shenoy","orcid":"0000-0001-5654-0629","position":84,"is_corresponding":false},{"id":1320749,"name":"R Sheridan","orcid":null,"position":85,"is_corresponding":false},{"id":1320750,"name":"Shubhra Srivastava-Malhotra","orcid":null,"position":86,"is_corresponding":false},{"id":274766,"name":"Surya P. Bhatt","orcid":"0000-0002-8418-4497","position":87,"is_corresponding":false},{"id":527747,"name":"William C. Bailey","orcid":null,"position":88,"is_corresponding":false},{"id":312801,"name":"Sandeep Bodduluri","orcid":null,"position":89,"is_corresponding":false},{"id":250085,"name":"Mark T. Dransfield","orcid":"0000-0002-9207-1820","position":91,"is_corresponding":false},{"id":285680,"name":"Scott Grumley","orcid":"0000-0001-8285-2423","position":92,"is_corresponding":false},{"id":1320751,"name":"Sonya Hardy","orcid":null,"position":93,"is_corresponding":false},{"id":641977,"name":"Anand Iyer","orcid":"0000-0001-7700-0728","position":94,"is_corresponding":false},{"id":267139,"name":"David C. LaFon","orcid":"0000-0001-5174-1931","position":95,"is_corresponding":false},{"id":1210982,"name":"Padma P. Manapragada","orcid":"0000-0003-0915-0550","position":96,"is_corresponding":false},{"id":285678,"name":"Hrudaya Nath","orcid":"0000-0003-0069-4068","position":98,"is_corresponding":false},{"id":319956,"name":"Gabriela R. Oates","orcid":"0000-0003-4052-1524","position":99,"is_corresponding":false},{"id":892798,"name":"Nicholas Enzer","orcid":"0009-0006-8082-2486","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:07:02.142014Z","pmid":"39097658","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}