{"doi":"10.1038/s41598-024-57252-2","title":"Gait-related beta-gamma phase amplitude coupling in the subthalamic nucleus of parkinsonian patients","abstract":"<jats:title>Abstract</jats:title><jats:p>Analysis of coupling between the phases and amplitudes of neural oscillations has gained increasing attention as an important mechanism for large-scale brain network dynamics. In Parkinson’s disease (PD), preliminary evidence indicates abnormal beta-phase coupling to gamma-amplitude in different brain areas, including the subthalamic nucleus (STN). We analyzed bilateral STN local field potentials (LFPs) in eight subjects with PD chronically implanted with deep brain stimulation electrodes during upright quiet standing and unperturbed walking. Phase-amplitude coupling (PAC) was computed using the Kullback-Liebler method, based on the modulation index. Neurophysiological recordings were correlated with clinical and kinematic measurements and individual molecular brain imaging studies ([<jats:sup>123</jats:sup>I]FP-CIT and single-photon emission computed tomography). We showed a dopamine-related increase in subthalamic beta-gamma PAC from standing to walking. Patients with poor PAC modulation and low PAC during walking spent significantly more time in the stance and double support phase of the gait cycle. Our results provide new insights into the subthalamic contribution to human gait and suggest cross-frequency coupling as a gateway mechanism to convey patient-specific information of motor control for human locomotion.</jats:p>","journal":"Scientific Reports","year":2024,"id":651597,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1699443,"name":"Chiara Palmisano","orcid":null,"position":1,"is_corresponding":false},{"id":1699445,"name":"Jasmin Del Vecchio Del Vecchio","orcid":null,"position":2,"is_corresponding":false},{"id":644705,"name":"Gianni Pezzoli","orcid":"0000-0003-4665-6710","position":3,"is_corresponding":false},{"id":632134,"name":"Jens Volkmann","orcid":"0000-0002-9570-593X","position":4,"is_corresponding":false},{"id":1203014,"name":"Ioannis U. Isaias","orcid":"0000-0002-3552-5144","position":5,"is_corresponding":false},{"id":1699441,"name":"AmirAli Farokhniaee","orcid":"0000-0002-9653-0158","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Gait-related beta-gamma phase amplitude coupling in the subthalamic nucleus of parkinsonian patients","abstract":"<jats:title>Abstract</jats:title><jats:p>Analysis of coupling between the phases and amplitudes of neural oscillations has gained increasing attention as an important mechanism for large-scale brain network dynamics. In Parkinson’s disease (PD), preliminary evidence indicates abnormal beta-phase coupling to gamma-amplitude in different brain areas, including the subthalamic nucleus (STN). We analyzed bilateral STN local field potentials (LFPs) in eight subjects with PD chronically implanted with deep brain stimulation electrodes during upright quiet standing and unperturbed walking. Phase-amplitude coupling (PAC) was computed using the Kullback-Liebler method, based on the modulation index. Neurophysiological recordings were correlated with clinical and kinematic measurements and individual molecular brain imaging studies ([<jats:sup>123</jats:sup>I]FP-CIT and single-photon emission computed tomography). We showed a dopamine-related increase in subthalamic beta-gamma PAC from standing to walking. Patients with poor PAC modulation and low PAC during walking spent significantly more time in the stance and double support phase of the gait cycle. Our results provide new insights into the subthalamic contribution to human gait and suggest cross-frequency coupling as a gateway mechanism to convey patient-specific information of motor control for human locomotion.</jats:p>","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38509158","pmcid":null,"openalex_id":"https://openalex.org/W4393007605","authors":[],"funders":[],"total_grants":0,"fwci":2.9605,"citation_percentile":0.91679826,"influential_citations":0,"citation_trend":[{"year":2025,"count":8},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.nature.com/articles/s41598-024-57252-2.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/s41598-024-57252-2.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41598-024-57252-2","host_type":"publisher"},{"url":"https://doi.org/10.1038/s41598-024-57252-2","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38509158","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10954750","host_type":"repository"},{"url":"https://doaj.org/article/f880fe8ea01f48e2bce9d4f03556bad6","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10954750/pdf/41598_2024_Article_57252.pdf","host_type":"repository"}],"fields_of_study":["Neurological disorders and treatments","Neuroscience and Neural Engineering","Neural dynamics and brain function"],"mesh_terms":["Gait","Humans","Parkinson Disease","Walking","Subthalamic Nucleus","Deep Brain Stimulation"],"keywords":["Subthalamic nucleus","Deep brain stimulation","Neuroscience","Local field potential","Coupling (piping)","Kinematics","Parkinson's disease","Gait","Physics","Neurophysiology","BETA (programming language)","Electroencephalography","Beta Rhythm","Physical medicine and rehabilitation","Psychology","Medicine","Computer science","Internal medicine","Disease","Materials science"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"No poverty"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T10:06:08.970113Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}