{"doi":"10.1038/s41598-024-52175-4","title":"Investigating the causal relationship between physical activity and incident knee osteoarthritis: a two-sample Mendelian randomization study","abstract":"<jats:title>Abstract</jats:title><jats:p>There is evidence that physical activity (PA) has a long-term positive impact on disease. Whether PA is a risk factor for knee osteoarthritis (OA) is still controversial. The purpose of this study was to explore whether there is a causal relationship between PA and knee OA. We extracted PA and knee OA data from genome-wide association study (GWAS) databases. We used single-nucleotide polymorphisms (SNPs) as instrumental variables. We performed MR analysis by random-effects inverse-variance weighting (IVW), MR‒Egger, weighted median, simple mode, and weighted mode methods. We evaluated the stability and reliability of the results through sensitivity analysis. There was no significant association between PA and knee OA (p &gt; 0.05). We did not detect any pleiotropy (MR‒Egger intercept test et al.: p &gt; 0.05). The sensitivity analysis confirmed our results (p &gt; 0.05). There is no causal relationship between PA and knee OA.</jats:p>","journal":"Scientific Reports","year":2024,"id":636996,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1276763,"name":"Yuling Zhang","orcid":"0000-0003-4978-8866","position":1,"is_corresponding":false},{"id":1094466,"name":"Qian Li","orcid":"0009-0002-0336-4021","position":2,"is_corresponding":false},{"id":1653696,"name":"Liufang Huang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Investigating the causal relationship between physical activity and incident knee osteoarthritis: a two-sample Mendelian randomization study","abstract":"<jats:title>Abstract</jats:title><jats:p>There is evidence that physical activity (PA) has a long-term positive impact on disease. Whether PA is a risk factor for knee osteoarthritis (OA) is still controversial. The purpose of this study was to explore whether there is a causal relationship between PA and knee OA. We extracted PA and knee OA data from genome-wide association study (GWAS) databases. We used single-nucleotide polymorphisms (SNPs) as instrumental variables. We performed MR analysis by random-effects inverse-variance weighting (IVW), MR‒Egger, weighted median, simple mode, and weighted mode methods. We evaluated the stability and reliability of the results through sensitivity analysis. There was no significant association between PA and knee OA (p &gt; 0.05). We did not detect any pleiotropy (MR‒Egger intercept test et al.: p &gt; 0.05). The sensitivity analysis confirmed our results (p &gt; 0.05). There is no causal relationship between PA and knee OA.</jats:p>","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38238411","pmcid":"PMC10796638","openalex_id":"https://openalex.org/W4390967642","authors":[],"funders":[],"total_grants":0,"fwci":1.6648,"citation_percentile":0.82559575,"influential_citations":0,"citation_trend":[{"year":2024,"count":3},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.nature.com/articles/s41598-024-52175-4.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/s41598-024-52175-4.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41598-024-52175-4","host_type":"publisher"},{"url":"https://doi.org/10.1038/s41598-024-52175-4","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38238411","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10796638","host_type":"repository"},{"url":"https://doaj.org/article/f89b39a7e4ec462e882c31cca79a1064","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10796638/pdf/41598_2024_Article_52175.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10796638","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10796638?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Osteoarthritis Treatment and Mechanisms","Cancer-related molecular mechanisms research","Genetic Associations and Epidemiology","Humans","Genome-Wide Association Study","Mendelian Randomization Analysis","Osteoarthritis, Knee","Reproducibility of Results","Exercise","Polymorphism, Single Nucleotide"],"mesh_terms":["Humans","Reproducibility of Results","Exercise","Osteoarthritis, Knee","Polymorphism, Single Nucleotide","Genome-Wide Association Study","Mendelian Randomization Analysis"],"keywords":["Mendelian randomization","Genome-wide association study","Single-nucleotide polymorphism","Pleiotropy","Medicine","Meta-analysis","Osteoarthritis","Internal medicine","Genetics","Biology","Genotype","Genetic variants","Pathology","Gene","Phenotype"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T18:06:44.345026Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}