{"doi":"10.1038/s41598-023-28362-0","title":"Influence of social deprivation index on in-hospital outcomes of COVID-19","abstract":"While it is known that social deprivation index (SDI) plays an important role on risk for acquiring Coronavirus Disease 2019 (COVID-19), the impact of SDI on in-hospital outcomes such as intubation and mortality are less well-characterized. We analyzed electronic health record data of adults hospitalized with confirmed COVID-19 between March 1, 2020 and February 8, 2021 from the INSIGHT Clinical Research Network (CRN). To compute the SDI (exposure variable), we linked clinical data using patient's residential zip-code with social data at zip-code tabulation area. SDI is a composite of seven socioeconomic characteristics determinants at the zip-code level. For this analysis, we categorized SDI into quintiles. The two outcomes of interest were in-hospital intubation and mortality. For each outcome, we examined logistic regression and random forests to determine incremental value of SDI in predicting outcomes. We studied 30,016 included COVID-19 patients. In a logistic regression model for intubation, a model including demographics, comorbidity, and vitals had an Area under the receiver operating characteristic curve (AUROC) = 0.73 (95% CI 0.70-0.75); the addition of SDI did not improve prediction [AUROC = 0.73 (95% CI 0.71-0.75)]. In a logistic regression model for in-hospital mortality, demographics, comorbidity, and vitals had an AUROC = 0.80 (95% CI 0.79-0.82); the addition of SDI in Model 2 did not improve prediction [AUROC = 0.81 (95% CI 0.79-0.82)]. Random forests revealed similar findings. SDI did not provide incremental improvement in predicting in-hospital intubation or mortality. SDI plays an important role on who acquires COVID-19 and its severity; but once hospitalized, SDI appears less important.","journal":"Scientific Reports","year":2023,"id":336852,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6045,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":364894,"name":"Edward J. Schenck","orcid":"0000-0002-7950-5989","position":1,"is_corresponding":false},{"id":517045,"name":"Yiyuan Wu","orcid":null,"position":2,"is_corresponding":false},{"id":516358,"name":"Yongkang Zhang","orcid":"0000-0001-6312-9686","position":3,"is_corresponding":false},{"id":998509,"name":"Aayush Visaria","orcid":"0000-0002-2170-212X","position":4,"is_corresponding":false},{"id":690356,"name":"Duncan Orlander","orcid":null,"position":5,"is_corresponding":false},{"id":514576,"name":"Wenna Xi","orcid":"0000-0002-5427-5689","position":6,"is_corresponding":false},{"id":305709,"name":"Iván Díaz","orcid":"0000-0001-9056-2047","position":7,"is_corresponding":false},{"id":843314,"name":"Dmitry Morozyuk","orcid":null,"position":8,"is_corresponding":false},{"id":520533,"name":"Mark G. Weiner","orcid":"0000-0001-5586-9940","position":9,"is_corresponding":false},{"id":516361,"name":"Rainu Kaushal","orcid":"0000-0002-4694-2517","position":10,"is_corresponding":false},{"id":514577,"name":"Samprit Banerjee","orcid":"0000-0001-6936-0846","position":11,"is_corresponding":false},{"id":228353,"name":"Parag Goyal","orcid":"0000-0001-7474-3737","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-19T01:10:21.947540Z","pmid":"36720999","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}