{"doi":"10.1038/s41598-022-23922-2","title":"Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality","abstract":"Abstract Coronavirus disease-2019 (COVID-19) can be asymptomatic or lead to a wide symptom spectrum, including multi-organ damage and death. Here, we explored the potential of microRNAs in delineating patient condition and predicting clinical outcome. Plasma microRNA profiling of hospitalized COVID-19 patients showed that miR-144-3p was dynamically regulated in response to COVID-19. Thus, we further investigated the biomarker potential of miR-144-3p measured at admission in 179 COVID-19 patients and 29 healthy controls recruited in three centers. In hospitalized patients, circulating miR-144-3p levels discriminated between non-critical and critical illness (AUC miR-144-3p = 0.71; p = 0.0006), acting also as mortality predictor (AUC miR-144-3p = 0.67; p = 0.004). In non-hospitalized patients, plasma miR-144-3p levels discriminated mild from moderate disease (AUC miR-144-3p = 0.67; p = 0.03). Uncontrolled release of pro-inflammatory cytokines can lead to clinical deterioration. Thus, we explored the added value of a miR-144/cytokine combined analysis in the assessment of hospitalized COVID-19 patients. A miR-144-3p/Epidermal Growth Factor (EGF) combined score discriminated between non-critical and critical hospitalized patients (AUC miR-144-3p/EGF = 0.81; p < 0.0001); moreover, a miR-144-3p/Interleukin-10 (IL-10) score discriminated survivors from nonsurvivors (AUC miR-144-3p/IL-10 = 0.83; p < 0.0001). In conclusion, circulating miR-144-3p, possibly in combination with IL-10 or EGF, emerges as a noninvasive tool for early risk-based stratification and mortality prediction in COVID-19.","journal":"Scientific Reports","year":2022,"id":269390,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9559,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":932170,"name":"Simona Greco","orcid":"0000-0002-0275-7221","position":1,"is_corresponding":false},{"id":932171,"name":"Mélanie Vausort","orcid":"0000-0002-5261-7729","position":2,"is_corresponding":false},{"id":932172,"name":"Marios Miliotis","orcid":"0000-0003-4924-050X","position":3,"is_corresponding":false},{"id":932534,"name":"Eric Schordan","orcid":null,"position":4,"is_corresponding":false},{"id":932173,"name":"Shounak Baksi","orcid":"0000-0001-7225-5377","position":5,"is_corresponding":false},{"id":353522,"name":"Lu Zhang","orcid":"0000-0001-7141-6730","position":6,"is_corresponding":false},{"id":932174,"name":"Ekaterina Baryshnikova","orcid":"0000-0001-7476-2823","position":7,"is_corresponding":false},{"id":932175,"name":"Marco Ranucci","orcid":"0000-0002-4915-3572","position":8,"is_corresponding":false},{"id":932176,"name":"Rosanna Cardani","orcid":"0000-0001-8858-4327","position":9,"is_corresponding":false},{"id":932177,"name":"Guy Fagherazzi","orcid":"0000-0001-5033-5966","position":10,"is_corresponding":false},{"id":240212,"name":"Markus Ollert","orcid":"0000-0002-8055-0103","position":11,"is_corresponding":false},{"id":932178,"name":"Spyros Tastsoglou","orcid":"0000-0002-0316-6239","position":12,"is_corresponding":false},{"id":932179,"name":"Giannis Vatsellas","orcid":"0000-0002-1631-1060","position":13,"is_corresponding":false},{"id":228802,"name":"Artemis G. Hatzigeorgiou","orcid":"0000-0003-1414-5668","position":14,"is_corresponding":false},{"id":932535,"name":"Hüseyin Firat","orcid":null,"position":15,"is_corresponding":false},{"id":932180,"name":"Yvan Devaux","orcid":"0000-0002-5321-8543","position":16,"is_corresponding":false},{"id":932181,"name":"Fabio Martelli","orcid":"0000-0002-8624-7738","position":17,"is_corresponding":false},{"id":932169,"name":"Alisia Madè","orcid":"0000-0001-7854-8381","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T00:27:18.142851Z","pmid":"36414650","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}