{"doi":"10.1038/s41598-022-08066-7","title":"Early IFN-β administration protects cigarette smoke exposed mice against lethal influenza virus infection without increasing lung inflammation","abstract":"During influenza A virus (IAV) infection, it is unclear whether type I interferons (IFNs) have defensive antiviral effects or contribute to immunopathology in smokers. We treated nonsmoking (NS) and cigarette smoke (CS)-exposed mice intranasally with early (prophylactic) or late (therapeutic) IFN-β. We compared the mortality and innate immune responses of the treated mice following challenge with IAV. In NS mice, both early and late IFN-β administration decreased the survival rate in mice infected with IAV, with late IFN-β administration having the greatest effect on survival. In contrast, in CS-exposed mice, early IFN-β administration significantly increased survival during IAV infection while late IFN-β administration did not alter mortality. With regards to inflammation, in NS mice, IFN-β administration, especially late administration, significantly increased IAV-induced inflammation and lung injury. Early IFN-β administration to CS-exposed mice did not increase IAV-induced inflammation and lung injury as occurred in NS mice. Our results demonstrate, although IFN-β administration worsens the susceptibility of NS mice to influenza infection with increased immunopathology, early IFN-β administration to CS-exposed mice, which have suppression of the intrinsic IFN response, improved outcomes during influenza infection.","journal":"Scientific Reports","year":2022,"id":269186,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9616,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":502666,"name":"Lili Tian","orcid":"0000-0002-4686-5734","position":1,"is_corresponding":false},{"id":931931,"name":"Wei Zhang","orcid":"0000-0002-1960-4475","position":2,"is_corresponding":false},{"id":425219,"name":"J. Leland Booth","orcid":null,"position":3,"is_corresponding":false},{"id":693766,"name":"Jerry W. Ritchey","orcid":"0000-0003-0307-4673","position":4,"is_corresponding":false},{"id":931932,"name":"Shuhua Wu","orcid":"0000-0002-5480-9126","position":5,"is_corresponding":false},{"id":483634,"name":"Chao Xu","orcid":"0000-0003-0444-7080","position":6,"is_corresponding":false},{"id":423991,"name":"Brent R. Brown","orcid":"0000-0003-3742-3763","position":7,"is_corresponding":false},{"id":331378,"name":"Jordan P. Metcalf","orcid":"0000-0003-4359-5270","position":8,"is_corresponding":false},{"id":502664,"name":"Wenxin Wu","orcid":"0000-0001-6333-6773","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T00:27:18.142851Z","pmid":"35260752","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}