{"doi":"10.1038/s41598-021-94590-x","title":"The association of atherosclerotic cardiovascular disease and statin use with inflammation and treatment outcomes in tuberculosis","abstract":"Abstract Tuberculosis (TB) and atherosclerotic cardiovascular disease (ASCVD) have a close epidemiological and pathogenetic overlap. Thus, it becomes essential to understand the relationship between ASCVD and TB outcomes. From our retrospective cohort on drug-susceptible TB patients at the National Taiwan University Hospital, we assessed the association of pre-existing ASCVD (coronary artery disease (CAD) and atherothrombotic stroke (ATS)) with 9-month all-cause and infection-related mortality and the extent of mediation by systemic inflammatory markers. We determined the effect of pre-existing ASCVD on 2-month sputum microbiological status. Among ASCVD patients, we assessed the association of statin use on mortality. Nine-month all-cause mortality was higher in CAD patients with prior acute myocardial infarction (CAD + AMI + ) (adjusted HR 2.01, 95%CI 1.38–3.00) and ATS patients (aHR 2.79, 95%CI 1.92–4.07) and similarly, for infection-related mortality was higher in CAD + AMI + (aHR 1.95, 95%CI 1.17–3.24) and ATS (aHR 2.04, 95%CI 1.19–3.46) after adjusting for confounding factors. Pre-existing CAD (AMI - or AMI + ) or ATS did not change sputum culture conversion or sputum smear AFB positivity at 2 months. The CAD + AMI + group had significantly higher levels of CRP at TB diagnosis in the multivariable linear regression analysis (Adjusted B(SE) 1.24(0.62)). CRP mediated 66% ( P = 0.048) and 25% ( P = 0.033) of the association all-cause mortality with CAD + AMI − and CAD + AMI + , respectively. In summary, patients with ASCVD have higher hazards of 9-month all-cause and infection-related mortality, with elevated serum inflammation mediating one to three-quarters of this association when adjusted for confounders. Statin use was associated with lower all-cause mortality among patients with ASCVD.","journal":"Scientific Reports","year":2021,"id":173463,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9582,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":331270,"name":"Jennie Ruelas Castillo","orcid":"0000-0003-4570-205X","position":1,"is_corresponding":false},{"id":659444,"name":"Amudha Kumar","orcid":null,"position":2,"is_corresponding":false},{"id":712160,"name":"Justin Wei","orcid":null,"position":3,"is_corresponding":false},{"id":658836,"name":"Siqing Wang","orcid":"0000-0001-7311-6790","position":4,"is_corresponding":false},{"id":658833,"name":"Marie Gilbert Majella","orcid":"0000-0003-4036-5162","position":5,"is_corresponding":false},{"id":326390,"name":"Akshay Gupte","orcid":"0000-0002-5179-773X","position":6,"is_corresponding":false},{"id":231956,"name":"Jann‐Yuan Wang","orcid":"0000-0003-3406-366X","position":7,"is_corresponding":false},{"id":333926,"name":"Petros C. Karakousis","orcid":"0000-0003-1338-9206","position":8,"is_corresponding":false},{"id":378802,"name":"Vignesh Chidambaram","orcid":"0000-0002-4240-1027","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-18T23:46:49.903770Z","pmid":"34315941","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}