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Subtle but significant differences in alpha and beta diversity of the salivary microbiome were observed, with clear separation of depressed and healthy control cohorts into distinct clusters. A total of 21 bacterial taxa were found to be differentially abundant in the depressed cohort, including increased<jats:italic>Neisseria</jats:italic>spp. and<jats:italic>Prevotella nigrescens</jats:italic>, while 19 taxa had a decreased abundance. In this preliminary study we have shown that the composition of the oral microbiome is associated with depression in young adults. Further studies are now warranted, particuarly investigations into whether such shifts play any role in the underling aetiology of depression.</jats:p>","journal":"Scientific Reports","year":2021,"id":636200,"datarank":0.7009243251692859,"base_score":4.672828834461906,"endowment":4.672828834461906,"self_citation_contribution":0.7009243251692859,"citation_network_contribution":0.0,"self_endowment_contribution":0.7009243251692859,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":106,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1651011,"name":"Coral Lapsley","orcid":null,"position":1,"is_corresponding":false},{"id":775759,"name":"Andrew McDowell","orcid":"0000-0002-9339-1033","position":2,"is_corresponding":false},{"id":1041676,"name":"Georgios Miliotis","orcid":"0000-0002-0944-2206","position":3,"is_corresponding":false},{"id":727378,"name":"Margaret McLafferty","orcid":"0000-0001-8133-9353","position":4,"is_corresponding":false},{"id":1651012,"name":"Siobhan M. 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