{"doi":"10.1038/s41598-021-84792-8","title":"Field-deployable, rapid diagnostic testing of saliva for SARS-CoV-2","abstract":"To safely re-open economies and prevent future outbreaks, rapid, frequent, point-of-need, SARS-CoV-2 diagnostic testing is necessary. However, existing field-deployable COVID-19 testing methods require the use of uncomfortable swabs and trained providers in PPE, while saliva-based methods must be transported to high complexity laboratories for testing. Here, we report the development and clinical validation of High-Performance Loop-mediated isothermal Amplification (HP-LAMP), a rapid, saliva-based, SARS-CoV-2 test with a limit of detection of 1.4 copies of virus per µl of saliva and a sensitivity and specificity with clinical samples of > 96%, on par with traditional RT-PCR based methods using swabs, but can deliver results using only a single fluid transfer step and simple heat block. Testing of 120 patient samples in 40 pools comprised of 5 patient samples each with either all negative or a single positive patient sample was 100% accurate. Thus, HP-LAMP may enable rapid and accurate results in the field using saliva, without need of a high-complexity laboratory.","journal":"Scientific Reports","year":2021,"id":163508,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9608,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":229521,"name":"Hemant Suryawanshi","orcid":null,"position":1,"is_corresponding":false},{"id":554173,"name":"Alexandre Djandji","orcid":"0000-0001-6854-3958","position":2,"is_corresponding":false},{"id":555074,"name":"Esther Kohl","orcid":null,"position":3,"is_corresponding":false},{"id":554174,"name":"Stephanie Morgan","orcid":"0000-0003-3124-0835","position":4,"is_corresponding":false},{"id":110274,"name":"Eldad A. Hod","orcid":"0000-0002-2367-9509","position":5,"is_corresponding":false},{"id":283476,"name":"Susan Whittier","orcid":null,"position":6,"is_corresponding":false},{"id":683331,"name":"Kevin A. Roth","orcid":"0000-0002-0643-995X","position":7,"is_corresponding":false},{"id":555075,"name":"Raymond T. Yeh","orcid":null,"position":8,"is_corresponding":false},{"id":555076,"name":"Juan Carlos Alejaldre","orcid":null,"position":9,"is_corresponding":false},{"id":555077,"name":"Elaine Fleck","orcid":null,"position":10,"is_corresponding":false},{"id":225936,"name":"Stephen A. Ferrara","orcid":"0000-0003-2287-8255","position":11,"is_corresponding":false},{"id":684126,"name":"Daniel Hercz","orcid":null,"position":12,"is_corresponding":false},{"id":642451,"name":"David Andrews","orcid":"0000-0003-1515-3694","position":13,"is_corresponding":false},{"id":412571,"name":"Lilly Lee","orcid":null,"position":14,"is_corresponding":false},{"id":684127,"name":"Kristopher A. Hendershot","orcid":null,"position":15,"is_corresponding":false},{"id":551809,"name":"Joshua Goldstein","orcid":"0000-0002-6179-2713","position":16,"is_corresponding":false},{"id":347303,"name":"Yousin Suh","orcid":"0000-0002-6014-3084","position":17,"is_corresponding":false},{"id":421808,"name":"Mahesh Mansukhani","orcid":"0000-0003-2044-0751","position":18,"is_corresponding":false},{"id":453287,"name":"Zev Williams","orcid":"0000-0001-8563-3250","position":19,"is_corresponding":false},{"id":453284,"name":"Shan Wei","orcid":"0000-0003-3239-406X","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-18T23:45:22.477398Z","pmid":"33750853","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}