{"doi":"10.1038/s41598-021-83093-4","title":"Antibody mediated activation of natural killer cells in malaria exposed pregnant women","abstract":"Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can induce Fc effector functions, including antibody-dependent cellular cytotoxicity, and the secretion of cytokines and chemokines. These effector functions are regulated by the composition of immunoglobulin G (IgG) Fc N-linked glycans. However, a role for antibody-mediated natural killer (NK) cells activation or Fc N-linked glycans in pregnant women with malaria has not yet been established. Herein, we studied the capacity of IgG antibodies from pregnant women, with placental malaria or non-placental malaria, to induce NK cell activation in response to placental malaria-associated antigens DBL2 and DBL3. Antibody-mediated NK cell activation was observed in pregnant women with malaria, but no differences were associated with susceptibility to placental malaria. Elevated anti-inflammatory glycosylation patterns of IgG antibodies were observed in pregnant women with or without malaria infection, which were not seen in healthy non-pregnant controls. This suggests that pregnancy-associated anti-inflammatory Fc N-linked glycans may dampen the antibody-mediated activation of NK cells in pregnant women with malaria infection. Overall, although anti-inflammatory glycans and antibody-dependent NK cell activation were detected in pregnant women with malaria, a definitive role for these antibody features in protecting against placental malaria remains to be proven.","journal":"Scientific Reports","year":2021,"id":172296,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9502,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":661495,"name":"Elizabeth H. Aitken","orcid":"0000-0002-2677-6208","position":1,"is_corresponding":false},{"id":603596,"name":"Wina Hasang","orcid":"0000-0001-8664-7558","position":2,"is_corresponding":false},{"id":707992,"name":"Ester López","orcid":"0000-0002-3573-1466","position":3,"is_corresponding":false},{"id":707993,"name":"Martin Killian","orcid":"0000-0001-7115-3248","position":4,"is_corresponding":false},{"id":605903,"name":"Holger W. Unger","orcid":"0000-0001-6347-536X","position":5,"is_corresponding":false},{"id":516476,"name":"Ali Salanti","orcid":"0000-0003-2207-5575","position":6,"is_corresponding":false},{"id":707994,"name":"Alexis Shub","orcid":"0000-0001-9719-5753","position":7,"is_corresponding":false},{"id":644151,"name":"Elizabeth McCarthy","orcid":"0000-0002-9175-5534","position":8,"is_corresponding":false},{"id":104934,"name":"Katherine Kedzierska","orcid":"0000-0001-6141-335X","position":9,"is_corresponding":false},{"id":639184,"name":"Martha Lappas","orcid":"0000-0002-4744-6929","position":10,"is_corresponding":false},{"id":108826,"name":"Stephen J. Kent","orcid":"0000-0002-8539-4891","position":11,"is_corresponding":false},{"id":406377,"name":"Stephen J. Rogerson","orcid":"0000-0003-4287-1982","position":12,"is_corresponding":false},{"id":536856,"name":"Amy W. Chung","orcid":"0000-0003-0020-9704","position":13,"is_corresponding":false},{"id":661496,"name":"Timon Damelang","orcid":"0000-0002-6150-4435","position":0,"is_corresponding":true}],"reference_count":104,"raw_metadata":null,"created_at":"2026-07-18T23:46:37.150824Z","pmid":"33602987","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}