{"doi":"10.1038/s41598-019-54886-5","title":"Chlamydia trachomatis serovars in urogenital and ocular samples collected 2014–2017 from Austrian patients","abstract":"<jats:title>Abstract</jats:title><jats:p>Infection of humans with <jats:italic>Chlamydia trachomatis</jats:italic>, a bacterial pathogen with a unique intracellular replication cycle, may cause a variety of clinical manifestations. These are linked to various serovars of the pathogen; trachoma to serovars A-C, oculogenital infections to serovars D-K, and lymphogranuloma venereum to serovars L1-L3. Nineteen serovars are known as human pathogens. The aim of the study was to determine the serovars of 401 <jats:italic>C. trachomatis</jats:italic> DNA positive extracts from original clinical specimens of patients in Austria including cervical and urethral swabs, urine, genital secretions and conjunctival swabs - collected from 2014 to 2017. Sequence analysis of the omp1 gene, encoding major outer-membrane protein was performed on each sample. In 50.1% of samples serovar E was identified and serovars F, D/Da and G/Ga were found in 16.2%, 9.7% and 9.0%, respectively. Remaining serovars were J (6.0%), K (4.7%), H (2.7%), B/Ba (1.0%), and I/Ia (0.5%). In 19 patients follow up samples could be tested. The majority of <jats:italic>C. trachomatis</jats:italic> serovars were associated with urogenital tract infections (D-K), however, one of them – serovar B/Ba - is linked to both, ocular and genital tract infection.</jats:p>","journal":"Scientific Reports","year":2019,"id":655650,"datarank":0.5495342469194471,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":0.0,"self_endowment_contribution":0.5495342469194471,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1711548,"name":"Anna-Margarita Schötta","orcid":null,"position":1,"is_corresponding":false},{"id":1421207,"name":"Hannes Stockinger","orcid":"0000-0001-6404-4430","position":2,"is_corresponding":false},{"id":1711549,"name":"Gerold Stanek","orcid":null,"position":3,"is_corresponding":false},{"id":1711550,"name":"Mateusz Markowicz","orcid":null,"position":4,"is_corresponding":false},{"id":1711547,"name":"Iwona Lesiak-Markowicz","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Chlamydia trachomatis serovars in urogenital and ocular samples collected 2014–2017 from Austrian patients","abstract":"<jats:title>Abstract</jats:title><jats:p>Infection of humans with <jats:italic>Chlamydia trachomatis</jats:italic>, a bacterial pathogen with a unique intracellular replication cycle, may cause a variety of clinical manifestations. These are linked to various serovars of the pathogen; trachoma to serovars A-C, oculogenital infections to serovars D-K, and lymphogranuloma venereum to serovars L1-L3. Nineteen serovars are known as human pathogens. The aim of the study was to determine the serovars of 401 <jats:italic>C. trachomatis</jats:italic> DNA positive extracts from original clinical specimens of patients in Austria including cervical and urethral swabs, urine, genital secretions and conjunctival swabs - collected from 2014 to 2017. Sequence analysis of the omp1 gene, encoding major outer-membrane protein was performed on each sample. In 50.1% of samples serovar E was identified and serovars F, D/Da and G/Ga were found in 16.2%, 9.7% and 9.0%, respectively. Remaining serovars were J (6.0%), K (4.7%), H (2.7%), B/Ba (1.0%), and I/Ia (0.5%). In 19 patients follow up samples could be tested. The majority of <jats:italic>C. trachomatis</jats:italic> serovars were associated with urogenital tract infections (D-K), however, one of them – serovar B/Ba - is linked to both, ocular and genital tract infection.</jats:p>","is_dataset_classified":null,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31798000","pmcid":"PMC6892924","openalex_id":"https://openalex.org/W2993981509","authors":[],"funders":[],"total_grants":0,"fwci":1.6908,"citation_percentile":0.82510361,"influential_citations":0,"citation_trend":[{"year":2021,"count":5},{"year":2022,"count":7},{"year":2023,"count":7},{"year":2024,"count":7},{"year":2025,"count":8},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.nature.com/articles/s41598-019-54886-5.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/s41598-019-54886-5.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41598-019-54886-5","host_type":"publisher"},{"url":"https://doi.org/10.1038/s41598-019-54886-5","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31798000","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6892924","host_type":"repository"},{"url":"https://doaj.org/article/556e471f21164da2b07e17f00284be90","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6892924","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6892924?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Reproductive tract infections research","Urinary Tract Infections Management","Syphilis Diagnosis and Treatment"],"mesh_terms":["Adolescent","Adult","Aged","Austria","Chlamydia Infections","Chlamydia trachomatis","Conjunctiva","Female","Humans","Male","Middle Aged","Urogenital System","Young Adult","Serogroup"],"keywords":["Serotype","Chlamydia trachomatis","Lymphogranuloma venereum","Trachoma","Pathogen","Chlamydia","Virology","Microbiology","Genitourinary system","Biology","Sex organ","Chlamydiaceae","Medicine","Immunology","Pathology","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T18:26:15.909347Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}