{"doi":"10.1038/s41598-017-05912-x","title":"Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks","abstract":"<jats:title>Abstract</jats:title><jats:p>TGFβ1 is a key regulator for induction of tissue remodeling after dermal wounding. We present a model of paracrine delivery of TGFβ1 for differentiation of dermal fibroblasts based on a fibrillar 3D collagen matrix and embedded TGFβ1 releasing microparticles. We found differentiation into myofibroblasts was achieved in a TGFβ1 dependent manner at much lower doses than systemic delivery. This effect is accounted to the slow and sustained TGFβ1 release mimicking paracrine cell signals.</jats:p>","journal":"Scientific Reports","year":2017,"id":671950,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":246177,"name":"Jiranuwat Sapudom","orcid":"0000-0001-6627-7713","position":1,"is_corresponding":false},{"id":1755519,"name":"Marina Chkolnikov","orcid":null,"position":2,"is_corresponding":false},{"id":1755520,"name":"Martin Wilde","orcid":null,"position":3,"is_corresponding":false},{"id":1755521,"name":"Ulf Anderegg","orcid":null,"position":4,"is_corresponding":false},{"id":1755522,"name":"Stephanie Möller","orcid":null,"position":5,"is_corresponding":false},{"id":1755523,"name":"Matthias Schnabelrauch","orcid":null,"position":6,"is_corresponding":false},{"id":1755524,"name":"Tilo Pompe","orcid":null,"position":7,"is_corresponding":false},{"id":1755518,"name":"Michael Ansorge","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks","abstract":"<jats:title>Abstract</jats:title><jats:p>TGFβ1 is a key regulator for induction of tissue remodeling after dermal wounding. We present a model of paracrine delivery of TGFβ1 for differentiation of dermal fibroblasts based on a fibrillar 3D collagen matrix and embedded TGFβ1 releasing microparticles. We found differentiation into myofibroblasts was achieved in a TGFβ1 dependent manner at much lower doses than systemic delivery. This effect is accounted to the slow and sustained TGFβ1 release mimicking paracrine cell signals.</jats:p>","is_dataset_classified":null,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28720779","pmcid":"PMC5515936","openalex_id":"https://openalex.org/W2735977809","authors":[],"funders":[],"total_grants":0,"fwci":2.2668,"citation_percentile":0.87093516,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":4},{"year":2019,"count":2},{"year":2020,"count":4},{"year":2021,"count":3},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.nature.com/articles/s41598-017-05912-x.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/s41598-017-05912-x.pdf","host_type":"GOLD"},{"url":"https://www.nature.com/articles/s41598-017-05912-x.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41598-017-05912-x","host_type":"publisher"},{"url":"https://doi.org/10.1038/s41598-017-05912-x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28720779","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5515936","host_type":"repository"},{"url":"https://doaj.org/article/baad139bac064aadbbfd8a92a35b03b7","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5515936","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5515936?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Wound Healing and Treatments","Cellular Mechanics and Interactions","Tendon Structure and Treatment","Medicine","Chemistry","Engineering","Materials Science"],"mesh_terms":["Cell Differentiation","Cells, Cultured","Collagen","Humans","Skin","Signal Transduction","Paracrine Communication","Guided Tissue Regeneration","Transforming Growth Factor beta1","Myofibroblasts"],"keywords":["Paracrine signalling","Myofibroblast","Cell biology","Transforming growth factor","Chemistry","Cellular differentiation","Regulator","Extracellular matrix","Matrix (chemical analysis)","Biology","Fibrosis","Pathology","Medicine","Receptor","Biochemistry","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T05:31:04.542500Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}