{"doi":"10.1038/s41593-019-0491-3","title":"Single-cell transcriptomic profiling of the aging mouse brain","abstract":"The mammalian brain is complex, with multiple cell types performing a variety of diverse functions, but exactly how each cell type is affected in aging remains largely unknown. Here we performed a single-cell transcriptomic analysis of young and old mouse brains. We provide comprehensive datasets of aging-related genes, pathways and ligand-receptor interactions in nearly all brain cell types. Our analysis identified gene signatures that vary in a coordinated manner across cell types and gene sets that are regulated in a cell-type specific manner, even at times in opposite directions. These data reveal that aging, rather than inducing a universal program, drives a distinct transcriptional course in each cell population, and they highlight key molecular processes, including ribosome biogenesis, underlying brain aging. Overall, these large-scale datasets (accessible online at https://portals.broadinstitute.org/single_cell/study/aging-mouse-brain ) provide a resource for the neuroscience community that will facilitate additional discoveries directed towards understanding and modifying the aging process.","journal":"Nature Neuroscience","year":2019,"id":8884,"datarank":9.469558906016013,"base_score":6.612041034833092,"endowment":6.612041034833092,"self_citation_contribution":0.9918061552249638,"citation_network_contribution":8.47775275079105,"self_endowment_contribution":0.9918061552249638,"citer_contribution":8.47775275079105,"corpus_percentile":77.379983726607,"corpus_rank":279,"citation_count":778,"citer_count":198,"citers_with_citation_signal":198,"citers_with_endowment":198,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7421,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2019-09-24","algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":68237,"name":"Scott L. Lipnick","orcid":"0000-0002-4271-746X","position":1,"is_corresponding":false},{"id":76034,"name":"Brendan T. Innes","orcid":"0000-0003-2496-3154","position":2,"is_corresponding":false},{"id":11078,"name":"Sean K. Simmons","orcid":"0000-0002-1537-4000","position":3,"is_corresponding":false},{"id":50708,"name":"Xian Adiconis","orcid":"0000-0002-4052-2503","position":4,"is_corresponding":false},{"id":2276,"name":"Danielle Dionne","orcid":"0000-0002-8338-4323","position":5,"is_corresponding":false},{"id":76035,"name":"Brittany A. Mayweather","orcid":"0000-0003-1189-2828","position":6,"is_corresponding":false},{"id":76036,"name":"Zachary Niziolek","orcid":"0000-0002-7361-9686","position":8,"is_corresponding":false},{"id":68231,"name":"Ceren Ozek","orcid":"0000-0002-0336-004X","position":9,"is_corresponding":false},{"id":48125,"name":"Vincent L. Butty","orcid":"0000-0003-1173-2429","position":10,"is_corresponding":false},{"id":53880,"name":"Ruth Isserlin","orcid":"0000-0002-6805-2080","position":11,"is_corresponding":false},{"id":68238,"name":"Sean M. Buchanan","orcid":"0000-0002-0171-3382","position":12,"is_corresponding":false},{"id":62836,"name":"Stuart S. Levine","orcid":"0000-0001-7363-562X","position":13,"is_corresponding":false},{"id":29633,"name":"Prisca Liberali","orcid":"0000-0003-0695-6081","position":14,"is_corresponding":false},{"id":13079,"name":"Samirkumar B. Amin","orcid":"0000-0002-3207-9505","position":15,"is_corresponding":false},{"id":11089,"name":"Joshua Z. Levin","orcid":"0000-0002-0170-3598","position":16,"is_corresponding":false},{"id":68239,"name":"Lee L. Rubin","orcid":"0000-0002-8658-841X","position":17,"is_corresponding":false},{"id":2284,"name":"Lan Nguyễn","orcid":"0000-0002-1791-0436","position":20,"is_corresponding":false},{"id":68228,"name":"Methodios Ximerakis","orcid":"0000-0002-2815-7558","position":0,"is_corresponding":true}],"reference_count":102,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}