{"doi":"10.1038/s41592-019-0548-y","title":"High-definition spatial transcriptomics for in situ tissue profiling","abstract":"Spatial and molecular characteristics determine tissue function, yet high-resolution methods to capture both concurrently are lacking. Here, we developed high-definition spatial transcriptomics, which captures RNA from histological tissue sections on a dense, spatially barcoded bead array. Each experiment recovers several hundred thousand transcript-coupled spatial barcodes at 2-μm resolution, as demonstrated in mouse brain and primary breast cancer. This opens the way to high-resolution spatial analysis of cells and tissues.","journal":"Nature Methods","year":2019,"id":9855,"datarank":1.0631360558336962,"base_score":7.087573705557973,"endowment":7.087573705557973,"self_citation_contribution":1.0631360558336962,"citation_network_contribution":0.0,"self_endowment_contribution":1.0631360558336962,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1196,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.1866,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2019-09-09","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":484,"name":"Gökçen Eraslan","orcid":"0000-0001-9579-2909","position":1,"is_corresponding":false},{"id":474,"name":"Fredrik Salmén","orcid":"0000-0001-8728-3709","position":2,"is_corresponding":false},{"id":472,"name":"Johanna Klughammer","orcid":"0000-0002-3628-9278","position":3,"is_corresponding":false},{"id":473,"name":"Linnea Stenbeck","orcid":"0000-0002-0210-7886","position":4,"is_corresponding":false},{"id":28660,"name":"Denis Schapiro","orcid":"0000-0002-9391-5722","position":5,"is_corresponding":false},{"id":475,"name":"Tarmo Äijö","orcid":"0000-0002-3008-4634","position":6,"is_corresponding":false},{"id":476,"name":"Richard Bonneau","orcid":"0000-0003-4354-7906","position":7,"is_corresponding":false},{"id":477,"name":"Ludvig Bergenstråhle","orcid":"0000-0002-5108-4481","position":8,"is_corresponding":false},{"id":84718,"name":"José Fernandéz Navarro","orcid":"0000-0002-4035-5258","position":9,"is_corresponding":false},{"id":478,"name":"Joshua Gould","orcid":"0000-0001-9581-5461","position":10,"is_corresponding":false},{"id":18917,"name":"Gabriel K. Griffin","orcid":"0000-0002-4042-6757","position":11,"is_corresponding":false},{"id":14329,"name":"Åke Borg","orcid":"0000-0002-5793-132X","position":12,"is_corresponding":false},{"id":479,"name":"Mostafa Ronaghi","orcid":null,"position":13,"is_corresponding":false},{"id":480,"name":"Jonas Frisén","orcid":"0000-0001-5819-458X","position":14,"is_corresponding":false},{"id":481,"name":"Joakim Lundeberg","orcid":"0000-0003-4313-1601","position":15,"is_corresponding":false},{"id":29633,"name":"Prisca Liberali","orcid":"0000-0003-0695-6081","position":16,"is_corresponding":false},{"id":482,"name":"Patrik L. Ståhl","orcid":"0000-0002-2207-7370","position":17,"is_corresponding":false},{"id":483,"name":"Sanja Vicković","orcid":"0000-0003-0985-9885","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}