{"doi":"10.1038/s41591-024-03015-5","title":"Long-term kidney outcomes of semaglutide in obesity and cardiovascular disease in the SELECT trial","abstract":"Abstract The SELECT trial previously reported a 20% reduction in major adverse cardiovascular events with semaglutide ( n = 8,803) versus placebo ( n = 8,801) in patients with overweight/obesity and established cardiovascular disease, without diabetes. In the present study, we examined the effect of once-weekly semaglutide 2.4 mg on kidney outcomes in the SELECT trial. The incidence of the pre-specified main composite kidney endpoint (death from kidney disease, initiation of chronic kidney replacement therapy, onset of persistent estimated glomerular filtration rate (eGFR) < 15 ml min −1 1.73 m − 2 , persistent ≥50% reduction in eGFR or onset of persistent macroalbuminuria) was lower with semaglutide (1.8%) versus placebo (2.2%): hazard ratio (HR) = 0.78; 95% confidence interval (CI) 0.63, 0.96; P = 0.02. The treatment benefit at 104 weeks for eGFR was 0.75 ml min −1 1.73 m − 2 (95% CI 0.43, 1.06; P < 0.001) overall and 2.19 ml min −1 1.73 m − 2 (95% CI 1.00, 3.38; P < 0.001) in patients with baseline eGFR <60 ml min −1 1.73 m − 2 . These results suggest a benefit of semaglutide on kidney outcomes in individuals with overweight/obesity, without diabetes. ClinicalTrials.gov identifier: NCT03574597 .","journal":"Nature Medicine","year":2024,"id":416233,"datarank":4.572219625560338,"base_score":5.3230099791384085,"endowment":5.3230099791384085,"self_citation_contribution":0.7984514968707613,"citation_network_contribution":3.773768128689577,"self_endowment_contribution":0.7984514968707613,"citer_contribution":3.773768128689577,"corpus_percentile":null,"corpus_rank":null,"citation_count":204,"citer_count":100,"citers_with_citation_signal":100,"citers_with_endowment":100,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03574597"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":231195,"name":"Ildiko Lingvay","orcid":"0000-0001-7006-7401","position":1,"is_corresponding":false},{"id":1199331,"name":"Paul Brown","orcid":"0000-0001-8237-5065","position":2,"is_corresponding":false},{"id":355999,"name":"John Deanfield","orcid":"0000-0001-8806-6052","position":3,"is_corresponding":false},{"id":34496,"name":"Kirstine Brown‐Frandsen","orcid":"0000-0002-1752-2054","position":4,"is_corresponding":false},{"id":249041,"name":"Steven E. Kahn","orcid":"0000-0001-7307-9002","position":5,"is_corresponding":false},{"id":501379,"name":"Jorge Plutzky","orcid":"0000-0002-7194-9876","position":6,"is_corresponding":false},{"id":644859,"name":"Koichi Node","orcid":"0000-0002-2534-0939","position":7,"is_corresponding":false},{"id":2623,"name":"Alexander Parkhomenko","orcid":"0000-0002-3563-9627","position":8,"is_corresponding":false},{"id":1199332,"name":"Lars Rydén","orcid":"0000-0002-5430-4697","position":9,"is_corresponding":false},{"id":1030639,"name":"John Wilding","orcid":"0000-0003-2839-8404","position":10,"is_corresponding":false},{"id":34487,"name":"Johannes F.E. Mann","orcid":"0000-0002-3154-5332","position":11,"is_corresponding":false},{"id":231214,"name":"Katherine R. Tuttle","orcid":"0000-0002-2235-0103","position":12,"is_corresponding":false},{"id":273070,"name":"Thomas Idorn","orcid":null,"position":13,"is_corresponding":false},{"id":1200446,"name":"Naveen Rathor","orcid":null,"position":14,"is_corresponding":false},{"id":1021343,"name":"A. Michael Lincoff","orcid":"0000-0001-8175-2121","position":15,"is_corresponding":false},{"id":594596,"name":"Helen M. Colhoun","orcid":"0000-0002-8345-3288","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T01:56:20.964471Z","pmid":"38796653","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}