{"doi":"10.1038/s41591-022-02075-9","title":"CSF tau microtubule-binding region identifies pathological changes in primary tauopathies","abstract":"Abstract Despite recent advances in fluid biomarker research in Alzheimer’s disease (AD), there are no fluid biomarkers or imaging tracers with utility for diagnosis and/or theragnosis available for other tauopathies. Using immunoprecipitation and mass spectrometry, we show that 4 repeat (4R) isoform-specific tau species from microtubule-binding region (MTBR-tau 275 and MTBR-tau 282 ) increase in the brains of corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), frontotemporal lobar degeneration (FTLD)- MAPT and AD but decrease inversely in the cerebrospinal fluid (CSF) of CBD, FTLD- MAPT and AD compared to control and other FTLD-tau (for example, Pick’s disease). CSF MTBR-tau measures are reproducible in repeated lumbar punctures and can be used to distinguish CBD from control (receiver operating characteristic area under the curve (AUC) = 0.889) and other FTLD-tau, such as PSP (AUC = 0.886). CSF MTBR-tau 275 and MTBR-tau 282 may represent the first affirmative biomarkers to aid in the diagnosis of primary tauopathies and facilitate clinical trial designs.","journal":"Nature Medicine","year":2022,"id":234643,"datarank":0.6862066467755076,"base_score":4.574710978503383,"endowment":4.574710978503383,"self_citation_contribution":0.6862066467755076,"citation_network_contribution":0.0,"self_endowment_contribution":0.6862066467755076,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":96,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":228356,"name":"Nicolas R. Barthélemy","orcid":"0000-0003-4937-2860","position":1,"is_corresponding":false},{"id":260466,"name":"Salvatore Spina","orcid":"0000-0003-3570-9143","position":2,"is_corresponding":false},{"id":615492,"name":"Lawren VandeVrede","orcid":"0000-0002-8304-6711","position":3,"is_corresponding":false},{"id":850953,"name":"Yingxin He","orcid":"0000-0003-2543-4553","position":4,"is_corresponding":false},{"id":297184,"name":"Ross W. Paterson","orcid":"0000-0001-9372-3635","position":5,"is_corresponding":false},{"id":722017,"name":"Brenton A. Wright","orcid":"0000-0002-0825-6524","position":6,"is_corresponding":false},{"id":321439,"name":"Gregory S. Day","orcid":"0000-0001-5133-5538","position":7,"is_corresponding":false},{"id":250202,"name":"Albert A. Davis","orcid":"0000-0003-2042-8445","position":8,"is_corresponding":false},{"id":301876,"name":"Celeste M. Karch","orcid":"0000-0002-6854-5547","position":9,"is_corresponding":false},{"id":32591,"name":"William W. Seeley","orcid":"0000-0003-1410-2027","position":10,"is_corresponding":false},{"id":308303,"name":"Richard J. Perrin","orcid":"0000-0002-3443-7716","position":11,"is_corresponding":false},{"id":850954,"name":"Rama K. Koppisetti","orcid":"0000-0002-7539-4572","position":12,"is_corresponding":false},{"id":851977,"name":"Faris Shaikh","orcid":null,"position":13,"is_corresponding":false},{"id":616959,"name":"Argentina Lario Lago","orcid":null,"position":14,"is_corresponding":false},{"id":253906,"name":"Hilary W. Heuer","orcid":"0000-0002-3776-1685","position":15,"is_corresponding":false},{"id":253916,"name":"Nupur Ghoshal","orcid":"0000-0002-6680-6731","position":16,"is_corresponding":false},{"id":238275,"name":"Audrey Gabelle","orcid":"0000-0002-7648-9194","position":17,"is_corresponding":false},{"id":58513,"name":"Bruce L. Miller","orcid":"0000-0002-2152-4220","position":18,"is_corresponding":false},{"id":253908,"name":"Adam L. Boxer","orcid":"0000-0002-1215-5064","position":19,"is_corresponding":false},{"id":228359,"name":"Randall J. Bateman","orcid":"0000-0002-7729-1702","position":20,"is_corresponding":false},{"id":228358,"name":"Chihiro Sato","orcid":"0000-0002-7639-8727","position":21,"is_corresponding":false},{"id":228357,"name":"Kanta Horie","orcid":"0000-0001-7736-2614","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:21:42.662304Z","pmid":"36424467","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}