{"doi":"10.1038/s41590-024-02075-6","title":"Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation","abstract":"Abstract Regulatory T (T reg ) cells are a specialized CD4 + T cell lineage with essential anti-inflammatory functions. Analysis of T reg cell adaptations to non-lymphoid tissues that enable their specialized immunosuppressive and tissue-supportive functions raises questions about the underlying mechanisms of these adaptations and whether they represent stable differentiation or reversible activation states. Here, we characterize distinct colonic effector T reg cell transcriptional programs. Attenuated T cell receptor (TCR) signaling and acquisition of substantial TCR-independent functionality seems to facilitate the terminal differentiation of a population of colonic effector T reg cells that are distinguished by stable expression of the immunomodulatory cytokine IL-10. Functional studies show that this subset of effector T reg cells, but not their expression of IL-10, is indispensable for colonic health. These findings identify core features of the terminal differentiation of effector T reg cells in non-lymphoid tissues and their function.","journal":"Nature Immunology","year":2025,"id":510739,"datarank":0.6605549382350842,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.21888909136011805,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.21888909136011805,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":15,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9509,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1368479,"name":"Aazam P. Ghelani","orcid":null,"position":1,"is_corresponding":false},{"id":235390,"name":"Andrew G. Levine","orcid":"0000-0003-3717-7558","position":2,"is_corresponding":false},{"id":803889,"name":"Stephen Martis","orcid":"0000-0003-1735-2347","position":3,"is_corresponding":false},{"id":636462,"name":"Paolo Giovanelli","orcid":"0000-0002-5799-6721","position":4,"is_corresponding":false},{"id":145143,"name":"Zhong-Min Wang","orcid":null,"position":5,"is_corresponding":false},{"id":548,"name":"Giorgi Beroshvili","orcid":"0000-0002-8038-1493","position":6,"is_corresponding":false},{"id":349760,"name":"Yuri Pritykin","orcid":"0000-0001-6589-981X","position":7,"is_corresponding":false},{"id":56492,"name":"Chirag Krishna","orcid":"0000-0002-9166-4632","position":8,"is_corresponding":false},{"id":1178519,"name":"Xiao Jun Huang","orcid":"0000-0003-1906-5819","position":9,"is_corresponding":false},{"id":273568,"name":"Ariella Glasner","orcid":"0000-0001-7122-881X","position":10,"is_corresponding":false},{"id":86527,"name":"Benjamin D. Greenbaum","orcid":"0000-0001-6153-8793","position":11,"is_corresponding":false},{"id":43058,"name":"Christina S. Leslie","orcid":"0000-0002-4571-5910","position":12,"is_corresponding":false},{"id":90403,"name":"Alexander Y. Rudensky","orcid":"0000-0003-1280-2898","position":13,"is_corresponding":false},{"id":1367852,"name":"Stanislav Dikiy","orcid":"0000-0002-8287-6561","position":0,"is_corresponding":true}],"reference_count":117,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:47:50.575618Z","pmid":"39905200","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}