{"doi":"10.1038/s41589-020-00693-3","title":"Ion channels as lipid sensors: from structures to mechanisms","abstract":null,"journal":"Nature Chemical Biology","year":2020,"id":644373,"datarank":2.3417359638020767,"base_score":4.290459441148391,"endowment":4.290459441148391,"self_citation_contribution":0.6435689161722588,"citation_network_contribution":1.6981670476298178,"self_endowment_contribution":0.6435689161722588,"citer_contribution":1.6981670476298178,"corpus_percentile":null,"corpus_rank":null,"citation_count":72,"citer_count":67,"citers_with_citation_signal":63,"citers_with_endowment":63,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1677158,"name":"John E. Baenziger","orcid":"0000-0002-2888-5328","position":1,"is_corresponding":false},{"id":1677155,"name":"Mackenzie J. Thompson","orcid":"0000-0001-8421-4222","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Ion channels as lipid sensors: from structures to mechanisms","abstract":"Ion channels play critical roles in cellular function by facilitating the flow of ions across the membrane in response to chemical or mechanical stimuli. Ion channels operate in a lipid bilayer, which can modulate or define their function. Recent technical advancements have led to the solution of numerous ion channel structures solubilized in detergent and/or reconstituted into lipid bilayers, thus providing unprecedented insight into the mechanisms underlying ion channel-lipid interactions. Here, we describe how ion channel structures have evolved to respond to both lipid modulators and lipid activators to control the electrical activities of cells, highlighting diverse mechanisms and common themes.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33199909","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","grant_id":"113312","title":null},{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"unidentified","title":"unidentified"}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"Springer Nature TDM","oa_locations":[{"url":"https://www.nature.com/articles/s41589-020-00693-3.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41589-020-00693-3","host_type":"publisher"},{"url":"https://doi.org/10.1038/s41589-020-00693-3","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/33199909","host_type":""},{"url":"https://dx.doi.org/10.1038/s41589-020-00693-3","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Cell Membrane","Eukaryotic Cells","Animals","Mammals","Humans","Lipid Bilayers","Phosphatidylinositol Phosphates","Potassium Channels, Tandem Pore Domain","Potassium Channels, Voltage-Gated","Cell Communication","Signal Transduction","Binding Sites","Protein Binding","Models, Molecular","G Protein-Coupled Inwardly-Rectifying Potassium Channels","Protein Interaction Domains and Motifs","Protein Conformation, alpha-Helical","Protein Conformation, beta-Strand"],"keywords":["Mammals","Models, Molecular","Protein Conformation, alpha-Helical","Binding Sites","Cell Membrane","Lipid Bilayers","Cell Communication","Eukaryotic Cells","Potassium Channels, Tandem Pore Domain","G Protein-Coupled Inwardly-Rectifying Potassium Channels","Phosphatidylinositol Phosphates","Potassium Channels, Voltage-Gated","Animals","Humans","Protein Conformation, beta-Strand","Protein Interaction Domains and Motifs","Protein Binding","Signal Transduction"],"sdg_mappings":[{"sdg_number":6,"sdg_label":"6. Clean water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T01:02:05.779797Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}