{"doi":"10.1038/s41587-022-01261-x","title":"Haplotype-resolved assembly of diploid genomes without parental data","abstract":"Routine haplotype-resolved genome assembly from single samples remains an unresolved problem. Here we describe an algorithm that combines PacBio HiFi reads and Hi-C chromatin interaction data to produce a haplotype-resolved assembly without the sequencing of parents. Applied to human and other vertebrate samples, our algorithm consistently outperforms existing single-sample assembly pipelines and generates assemblies of similar quality to the best pedigree-based assemblies.","journal":"Nature Biotechnology","year":2022,"id":8438,"datarank":1.021686656790194,"base_score":6.811244378601294,"endowment":6.811244378601294,"self_citation_contribution":1.021686656790194,"citation_network_contribution":0.0,"self_endowment_contribution":1.021686656790194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":907,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0566,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-03-24","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":21329,"name":"Erich  D. Jarvis","orcid":"0000-0001-8931-5049","position":1,"is_corresponding":false},{"id":30838,"name":"Olivier Fédrigo","orcid":"0000-0002-6450-7551","position":2,"is_corresponding":false},{"id":14162,"name":"Lara Urban","orcid":"0000-0002-5445-9314","position":4,"is_corresponding":false},{"id":30840,"name":"Neil J. Gemmell","orcid":"0000-0003-0671-3637","position":5,"is_corresponding":false},{"id":30887,"name":"Alexandra P. Lewis","orcid":"0000-0002-6195-4786","position":6,"is_corresponding":false},{"id":30839,"name":"Klaus‐Peter Koepfli","orcid":"0000-0001-7281-0676","position":7,"is_corresponding":false},{"id":1288,"name":"Haoyu Cheng","orcid":"0000-0002-9209-5793","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}