{"doi":"10.1038/s41587-021-01037-9","title":"Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children","abstract":null,"journal":"Nature Biotechnology","year":2022,"id":630281,"datarank":0.8975904421030787,"base_score":5.983936280687191,"endowment":5.983936280687191,"self_citation_contribution":0.8975904421030787,"citation_network_contribution":0.0,"self_endowment_contribution":0.8975904421030787,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":396,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1632685,"name":"J. Röhmel","orcid":null,"position":1,"is_corresponding":false},{"id":617913,"name":"Soeren Lukassen","orcid":"0000-0001-7045-6327","position":2,"is_corresponding":false},{"id":1632686,"name":"S. Stricker","orcid":null,"position":3,"is_corresponding":false},{"id":1632687,"name":"V. G. Magalhães","orcid":null,"position":4,"is_corresponding":false},{"id":1632688,"name":"J. Liebig","orcid":"0000-0002-9188-036X","position":5,"is_corresponding":false},{"id":57946,"name":"Robert Lorenz Chua","orcid":"0000-0001-5945-9957","position":6,"is_corresponding":false},{"id":1632689,"name":"L. Thürmann","orcid":"0000-0003-1109-1924","position":7,"is_corresponding":false},{"id":1632690,"name":"M. Messingschlager","orcid":"0000-0002-7316-8192","position":8,"is_corresponding":false},{"id":1632691,"name":"A. Seegebarth","orcid":null,"position":9,"is_corresponding":false},{"id":1632692,"name":"B. Timmermann","orcid":null,"position":10,"is_corresponding":false},{"id":1632693,"name":"S. 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Children displayed higher basal expression of relevant pattern recognition receptors such as MDA5 (IFIH1) and RIG-I (DDX58) in upper airway epithelial cells, macrophages and dendritic cells, resulting in stronger innate antiviral responses upon SARS-CoV-2 infection than in adults. We further detected distinct immune cell subpopulations including KLRC1 (NKG2A)<sup>+</sup> cytotoxic T cells and a CD8<sup>+</sup> T cell population with a memory phenotype occurring predominantly in children. Our study provides evidence that the airway immune cells of children are primed for virus sensing, resulting in a stronger early innate antiviral response to SARS-CoV-2 infection than in adults.","is_dataset_classified":null,"base_score":5.983936280687191,"endowment":5.983936280687191,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34408314","pmcid":null,"openalex_id":"https://openalex.org/W3175817142","authors":[],"funders":[{"funder_name":"The Francis Crick Institute","grant_id":"10134","title":null},{"funder_name":"European Commission","grant_id":"874719","title":"Integrated and standardized NGS workflows for Personalised therapy"},{"funder_name":"BIH COVID-19 research program","grant_id":"","title":null},{"funder_name":"fightCOVID@DKFZ initiative","grant_id":"","title":null},{"funder_name":"Berlin Intitute of Health: BIH COVID-19 research program","grant_id":"","title":null}],"total_grants":5,"fwci":47.239,"citation_percentile":0.99941938,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":35},{"year":2022,"count":107},{"year":2023,"count":81},{"year":2024,"count":108},{"year":2025,"count":45},{"year":2026,"count":19}],"oa_status":"bronze","license":"Springer TDM","oa_locations":[{"url":"https://www.nature.com/articles/s41587-021-01037-9.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/s41587-021-01037-9.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41587-021-01037-9","host_type":"publisher"},{"url":"https://doi.org/10.1038/s41587-021-01037-9","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34408314","host_type":"repository"},{"url":"https://doi.org/10.1101/2021.06.24.21259087","host_type":""},{"url":"https://www.medrxiv.org/content/medrxiv/early/2021/06/28/2021.06.24.21259087.full.pdf","host_type":""},{"url":"https://dx.doi.org/10.1101/2021.06.24.21259087","host_type":""},{"url":"https://dx.doi.org/10.1038/s41587-021-01037-9","host_type":""},{"url":"https://hdl.handle.net/21.11116/0000-0009-1331-A","host_type":""},{"url":"https://hdl.handle.net/21.11116/0000-0009-1333-8","host_type":""}],"fields_of_study":["Respiratory viral infections research","Kawasaki Disease and Coronary Complications","COVID-19 Clinical Research Studies","0301 basic medicine","03 medical and health sciences","Adolescent","Adult","Aged","Bronchi","CD8-Positive T-Lymphocytes","COVID-19","Child","Child, Preschool","DEAD Box Protein 58","Dendritic Cells","Epithelial Cells","Female","Humans","Immunity, Innate","Infant","Infant, Newborn","Interferon-Induced Helicase, IFIH1","Macrophages","Male","Middle Aged","Receptors, Immunologic","SARS-CoV-2","Single-Cell Analysis","T-Lymphocytes, Cytotoxic","Young Adult"],"mesh_terms":["DEAD Box Protein 58","Interferon-Induced Helicase, IFIH1","COVID-19","SARS-CoV-2","Adolescent","Adult","Aged","Bronchi","Child","Child, Preschool","Dendritic Cells","Epithelial Cells","Female","Humans","Immunity, Innate","Infant","Infant, Newborn","Macrophages","Male","Middle Aged","Receptors, Immunologic","T-Lymphocytes, Cytotoxic","CD8-Positive T-Lymphocytes","Young Adult","Single-Cell Analysis"],"keywords":["Innate immune system","Immunity","Virology","Immunology","Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","Biology","Medicine","Coronavirus disease 2019 (COVID-19)","Immune system","Infectious disease (medical specialty)","Pathology","Disease","Adult","Male","Interferon-Induced Helicase, IFIH1","Adolescent","Macrophages","Infant, Newborn","COVID-19","Infant","Bronchi","Epithelial Cells","Dendritic Cells","CD8-Positive T-Lymphocytes","Middle Aged","Immunity, Innate","Child, Preschool","DEAD Box Protein 58","Humans","Female","Child","Aged"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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