{"doi":"10.1038/s41587-021-00943-2","title":"Adenine base editor engineering reduces editing of bystander cytosines","abstract":null,"journal":"Nature Biotechnology","year":2021,"id":604340,"datarank":0.7168685239667295,"base_score":4.77912349311153,"endowment":4.77912349311153,"self_citation_contribution":0.7168685239667295,"citation_network_contribution":0.0,"self_endowment_contribution":0.7168685239667295,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":118,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1550537,"name":"SeokHoon Lee","orcid":null,"position":1,"is_corresponding":false},{"id":1046164,"name":"Gue‐Ho Hwang","orcid":"0000-0002-4201-0974","position":2,"is_corresponding":false},{"id":1550538,"name":"Sung-Ah Hong","orcid":"0000-0002-3280-5677","position":3,"is_corresponding":false},{"id":1550539,"name":"Se-eun Park","orcid":null,"position":4,"is_corresponding":false},{"id":1028359,"name":"Jin‐Soo Kim","orcid":"0000-0003-4847-1306","position":5,"is_corresponding":false},{"id":1550540,"name":"Jae-Sung Woo","orcid":null,"position":6,"is_corresponding":false},{"id":396023,"name":"Sangsu Bae","orcid":"0000-0003-3615-8566","position":7,"is_corresponding":false},{"id":1334099,"name":"You Kyeong Jeong","orcid":"0000-0002-8788-3605","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Adenine base editor engineering reduces editing of bystander cytosines","abstract":"Adenine base editors (ABEs) catalyze specific A-to-G conversions at genomic sites of interest. However, ABEs also induce cytosine deamination at the target site. To reduce the cytosine editing activity, we engineered a commonly used adenosine deaminase, TadA7.10, and found that ABE7.10 with a D108Q mutation in TadA7.10 exhibited tenfold reduced cytosine deamination activity. The D108Q mutation also reduces cytosine deamination activity in two recently developed high-activity versions of ABE, ABE8e and ABE8s, and is compatible with V106W, a mutation that reduces off-target RNA editing. ABE7.10 containing a P48R mutation displayed increased cytosine deamination activity and a substantially reduced adenine editing rate, yielding a TC-specific base editing tool for TC-to-TT or TC-to-TG conversions that broadens the utility of base editors.","is_dataset_classified":null,"base_score":4.770684624465665,"endowment":4.770684624465665,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34211162","pmcid":null,"openalex_id":"https://openalex.org/W3173485772","authors":[],"funders":[{"funder_name":"National Research Foundation of Korea","grant_id":"2018R1C1B6004447","title":null},{"funder_name":"National Research Foundation of Korea","grant_id":"2021M3A9H3015389","title":null}],"total_grants":2,"fwci":5.3306,"citation_percentile":0.97143831,"influential_citations":0,"citation_trend":[{"year":2021,"count":4},{"year":2022,"count":16},{"year":2023,"count":26},{"year":2024,"count":26},{"year":2025,"count":32},{"year":2026,"count":13}],"oa_status":"closed","license":"https://www.springer.com/tdm","oa_locations":[{"url":"https://www.nature.com/articles/s41587-021-00943-2.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/s41587-021-00943-2","host_type":"publisher"},{"url":"https://doi.org/10.1038/s41587-021-00943-2","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34211162","host_type":"repository"},{"url":"https://hdl.handle.net/10371/179204","host_type":"repository"}],"fields_of_study":["CRISPR and Genetic Engineering","RNA Interference and Gene Delivery","Cytomegalovirus and herpesvirus research","Adenine","CRISPR-Cas Systems","Cytosine","Gene Editing","RNA Editing"],"mesh_terms":["Gene Editing","Adenine","Cytosine","RNA Editing","CRISPR-Cas Systems"],"keywords":["Bystander effect","Base (topology)","Computer science","Computational biology","Biology","Mathematics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T23:49:11.557292Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}